L-Moses dihydrochloride , CAS No.L659136

CAS: L659136 Cat. No.: L659136 Molecular Weight: 433.38

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Overview

L-Moses (L-45) dihydrochloride is the first potent, selective, and cell-active p300/CBP-associated factor ( PCAF ) bromodomain ( Brd ) inhibitor with a K d of 126 nM.

Appearance:Solid

IC50& Target:Brd 126 nM (Kd)

In Vitro:L-Moses (L-45) disrupts PCAF-Brd histone H3.3 interaction in cells using a nanoBRET assay, and a co-crystal structure of L-Moses with the homologous Brd Pf GCN5 from Plasmodium falciparum rationalizes the high selectivity for PCAF and GCN5 bromodomains. A

In Vivo:L-Moses (L-45) shows no observable cytotoxicity in peripheral blood mononuclear cells (PBMC), good cell-permeability, and metabolic stability in human and mouse liver microsomes, supporting its potential for in vivo use. MCE has not independently con

Biological Activity:L-Moses (L-45) dihydrochloride is the first potent, selective, and cell-active p300/CBP-associated factor ( PCAF ) bromodomain ( Brd ) inhibitor with a K d of 126 nM.

Specifications

Storage

Store at 2-8°C, Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Names and Identifiers

• Molecular Weight: 433.38