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Tgf-beta receptor type-1 (TGFBR1)

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  1. GSK 583, Inhibitor of receptor interacting serine/threonine kinase 2
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    GSK 583, Inhibitor of receptor interacting serine/threonine kinase 2
    CAS: 1346547-00-9 Formula: C20H19FN4O2S Molecular Weight: 398.45
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)
    In Stock Item #: G286537
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    IUPAC Name
    6-tert-butylsulfonyl-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine
    SMILES
    CC(C)(C)S(=O)(=O)C1=CC2=C(C=CN=C2C=C1)NC3=NNC4=C3C=C(C=C4)F
    InChIKey
    XLOGLWKOHPIJLV-UHFFFAOYSA-N
    InChI
    1S/C20H19FN4O2S/c1-20(2,3)28(26,27)13-5-7-16-14(11-13)17(8-9-22-16)23-19-15-10-12(21)4-6-18(15)24-25-19/h4-11H,1-3H3,(H2,22,23,24,25)
    Synonyms
    GSK 583 | GSK-2616583A
  2. LY2157299, TGF-beta receptor type I inhibitor
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    LY2157299, TGF-beta receptor type I inhibitor
    CAS: 700874-72-2 EC Number: 142-220-0 Formula: C22H19N5O Molecular Weight: 369.42
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    In Stock Item #: L126937
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    IUPAC Name
    4-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline-6-carboxamide
    SMILES
    CC1=NC(=CC=C1)C2=NN3CCCC3=C2C4=C5C=C(C=CC5=NC=C4)C(=O)N
    InChIKey
    IVRXNBXKWIJUQB-UHFFFAOYSA-N
    InChI
    1S/C22H19N5O/c1-13-4-2-5-18(25-13)21-20(19-6-3-11-27(19)26-21)15-9-10-24-17-8-7-14(22(23)28)12-16(15)17/h2,4-5,7-10,12H,3,6,11H2,1H3,(H2,23,28)
    Synonyms
    BDBM50015640 | 4-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[2,1-e]pyrazol-3-yl]quinoline-6-carboxamide | MFCD00...
  3. LY2109761, Inhibitor of transforming growth factor beta receptor 1;Inhibitor of transforming growth factor beta receptor 2
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    LY2109761, Inhibitor of transforming growth factor beta receptor 1;Inhibitor of transforming growth factor beta receptor 2
    CAS: 700874-71-1 Formula: C26H27N5O2 Molecular Weight: 441.52
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    In Stock Item #: L126135
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    IUPAC Name
    4-[2-[4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yl]oxyethyl]morpholine
    SMILES
    C1CC2=C(C(=NN2C1)C3=CC=CC=N3)C4=C5C=CC(=CC5=NC=C4)OCCN6CCOCC6
    InChIKey
    IHLVSLOZUHKNMQ-UHFFFAOYSA-N
    InChI
    1S/C26H27N5O2/c1-2-9-27-22(4-1)26-25(24-5-3-11-31(24)29-26)21-8-10-28-23-18-19(6-7-20(21)23)33-17-14-30-12-15-32-16-13-30/h1-2,4,6-10,18H,3,5,11-17H2
    Synonyms
    HMS3674E17 | SB19481 | AKOS022183732 | GTPL8075 | BCP9000868 | LY 2109761 | Q27082613 | .ALPHA.-KETOGLUCONIC ACID | Q...
  4. SB-505124 hydrochloride
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    SB-505124 hydrochloride
    CAS: 356559-13-2 PubChem CID: 16079009 Formula: C20H21N3O2HCl Molecular Weight: 371.86
    ≥97%
    In Stock Item #: T334804
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    IUPAC Name
    2-[4-(1,3-benzodioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl]-6-methylpyridine;hydrochloride
    SMILES
    CC1=NC(=CC=C1)C2=C(N=C(N2)C(C)(C)C)C3=CC4=C(C=C3)OCO4.Cl
    InChIKey
    BTUOOXPZOVNPMF-UHFFFAOYSA-N
    InChI
    1S/C20H21N3O2.ClH/c1-12-6-5-7-14(21-12)18-17(22-19(23-18)20(2,3)4)13-8-9-15-16(10-13)25-11-24-15;/h5-10H,11H2,1-4H3,(H,22,23);1H
    Synonyms
    2-(5-benzo[1,3]dioxol-5-yl-2-tert-butyl-3h-imidazol-4-yl)-6-methylpyridine hydrochloride | BCP19172 | SCHEMBL140197 |...
  5. SM 16
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    SM 16
    CAS: 614749-78-9 PubChem CID: 10387982 Formula: C25H26N4O3 Molecular Weight: 430.5
    ≥98%(HPLC)
    Out of Stock Item #: S287888
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    IUPAC Name
    4-[4-(1,3-benzodioxol-5-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl]bicyclo[2.2.2]octane-1-carboxamide
    SMILES
    CC1=NC(=CC=C1)C2=C(N=C(N2)C34CCC(CC3)(CC4)C(=O)N)C5=CC6=C(C=C5)OCO6
    InChIKey
    JUHTXZGCTPDXRU-UHFFFAOYSA-N
    InChI
    1S/C25H26N4O3/c1-15-3-2-4-17(27-15)21-20(16-5-6-18-19(13-16)32-14-31-18)28-23(29-21)25-10-7-24(8-11-25,9-12-25)22(26)30/h2-6,13H,7-12,14H2,1H3,(H2,26,show more
    Synonyms
    4-[4-(1,3-Benzodioxol-5-yl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-2-yl]bicyclo[2.2.2]octane-1-carboxamide
  6. GW788388
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    GW788388
    CAS: 452342-67-5 Formula: C25H23N5O2 Molecular Weight: 425.48
    ≥98%
    In Stock Item #: G125999
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    IUPAC Name
    N-(oxan-4-yl)-4-[4-(5-pyridin-2-yl-1H-pyrazol-4-yl)pyridin-2-yl]benzamide
    SMILES
    C1COCCC1NC(=O)C2=CC=C(C=C2)C3=NC=CC(=C3)C4=C(NN=C4)C5=CC=CC=N5
    InChIKey
    SAGZIBJAQGBRQA-UHFFFAOYSA-N
    InChI
    1S/C25H23N5O2/c31-25(29-20-9-13-32-14-10-20)18-6-4-17(5-7-18)23-15-19(8-12-27-23)21-16-28-30-24(21)22-3-1-2-11-26-22/h1-8,11-12,15-16,20H,9-10,13-14H2show more
    Synonyms
    FT-0700309 | HMS3656N21 | UNII-N14114957J | Q27284368 | N-(oxan-4-yl)-4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-...
  7. NVP-BHG712
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    NVP-BHG712
    CAS: 940310-85-0 EC Number: 804-395-8 Formula: C26H20F3N7O Molecular Weight: 503.48
    ≥98%
    In Stock Item #: N127928
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    IUPAC Name
    4-methyl-3-[(1-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide
    SMILES
    CC1=C(C=C(C=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)NC3=C4C=NN(C4=NC(=N3)C5=CN=CC=C5)C
    InChIKey
    ZCCPLJOKGAACRT-UHFFFAOYSA-N
    InChI
    1S/C26H20F3N7O/c1-15-8-9-16(25(37)32-19-7-3-6-18(12-19)26(27,28)29)11-21(15)33-23-20-14-31-36(2)24(20)35-22(34-23)17-5-4-10-30-13-17/h3-14H,1-2H3,(H,3show more
    Synonyms
    4-Methyl-3-(1-methyl-6-pyridin-3-yl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-N-(3-trifluoromethyl-phenyl)-benzamide | B...
  8. RepSox
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    RepSox
    CAS: 446859-33-2 EC Number: 663-924-9 Formula: C17H13N5 Molecular Weight: 287.32
    ≥98%
    In Stock Item #: R125531
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    IUPAC Name
    2-[5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]-1,5-naphthyridine
    SMILES
    CC1=NC(=CC=C1)C2=C(C=NN2)C3=NC4=C(C=C3)N=CC=C4
    InChIKey
    LBPKYPYHDKKRFS-UHFFFAOYSA-N
    InChI
    1S/C17H13N5/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14/h2-10H,1H3,(H,19,22)
    Synonyms
    ALK5 Inhibitor II | 2-(3-(6-methyl-2-pyridinyl)-1h-pyrazol-4-yl)-1,5-naphthyridine | DTXSID80332295 | AKOS016009677 |...
  9. SB431542 - ≥98%, used for , CAS No. 301836-41-9, by Aladdin Scientific
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    SB431542, Inhibitor of activin A receptor type 1C;Inhibitor of transforming growth factor beta receptor 1
    CAS: 301836-41-9 EC Number: 188-365-3 Formula: C22H16N4O3 Molecular Weight: 384.39
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: S125924
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    IUPAC Name
    4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide
    SMILES
    C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5
    InChIKey
    FHYUGAJXYORMHI-UHFFFAOYSA-N
    InChI
    1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26)
    Synonyms
    4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide | 4-[4-(1,3-BENZODIOXOL-5-YL)-5-(2-PYRIDI...
  10. SB505124, Inhibitor of transforming growth factor beta receptor 1
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    SB505124, Inhibitor of transforming growth factor beta receptor 1
    CAS: 694433-59-5 PubChem CID: 9858940 Formula: C20H21N3O2 Molecular Weight: 335.4
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: S126125
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    IUPAC Name
    2-[4-(1,3-benzodioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl]-6-methylpyridine
    SMILES
    CC1=NC(=CC=C1)C2=C(N=C(N2)C(C)(C)C)C3=CC4=C(C=C3)OCO4
    InChIKey
    WGZOTBUYUFBEPZ-UHFFFAOYSA-N
    InChI
    1S/C20H21N3O2/c1-12-6-5-7-14(21-12)18-17(22-19(23-18)20(2,3)4)13-8-9-15-16(10-13)25-11-24-15/h5-10H,11H2,1-4H3,(H,22,23)
    Synonyms
    HMS3655F08 | SCHEMBL373422 | AS-74679 | amino-4,6-dimethoxypyrimidine | CCG-267861 | TGF-beta RI Inhibitor III | etho...
  11. SB525334
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    SB525334
    CAS: 356559-20-1 EC Number: 636-855-7 PubChem CID: 9967941 Formula: C21H21N5 Molecular Weight: 343.42
    Solid ≥98%
    In Stock Item #: S129327
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    Technical Identifiers
    IUPAC Name
    6-[2-tert-butyl-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl]quinoxaline
    SMILES
    CC1=NC(=CC=C1)C2=C(N=C(N2)C(C)(C)C)C3=CC4=NC=CN=C4C=C3
    InChIKey
    DKPQHFZUICCZHF-UHFFFAOYSA-N
    InChI
    1S/C21H21N5/c1-13-6-5-7-16(24-13)19-18(25-20(26-19)21(2,3)4)14-8-9-15-17(12-14)23-11-10-22-15/h5-12H,1-4H3,(H,25,26)
    Synonyms
    6-(2-(tert-Butyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline
  12. SD-208, Inhibitor of transforming growth factor beta receptor 1
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    SD-208, Inhibitor of transforming growth factor beta receptor 1
    CAS: 627536-09-8 EC Number: 636-373-7 PubChem CID: 10316032 Formula: C17H10ClFN6 Molecular Weight: 352.75
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: S125587
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    IUPAC Name
    2-(5-chloro-2-fluorophenyl)-N-pyridin-4-ylpteridin-4-amine
    SMILES
    C1=CC(=C(C=C1Cl)C2=NC3=NC=CN=C3C(=N2)NC4=CC=NC=C4)F
    InChIKey
    BERLXWPRSBJFHO-UHFFFAOYSA-N
    InChI
    1S/C17H10ClFN6/c18-10-1-2-13(19)12(9-10)15-24-16-14(21-7-8-22-16)17(25-15)23-11-3-5-20-6-4-11/h1-9H,(H,20,22,23,24,25)
    Synonyms
    2-(5-chloro-2-fluorophenyl)-4-(4-pyridylamino)pteridine | BCP02214 | FT-0700345 | HMS3604B06 | 1608481-61-3 | 2-(5-Ch...
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