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Traf2 and nck-interacting protein kinase (TNIK)

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  1. URMC-099, Inhibitor of cyclin dependent kinase like 2;Inhibitor of death associated protein kinase 3;Inhibitor of fms related receptor tyrosine kinase 3;Inhibitor of leucine rich repeat kinase 2;Inhibitor of mitogen-activated protein kinase kinase kinase 10;Inhibit
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    URMC-099, Inhibitor of cyclin dependent kinase like 2;Inhibitor of death associated protein kinase 3;Inhibitor of fms related receptor tyrosine kinase 3;Inhibitor of leucine rich repeat kinase 2;Inhibitor of mitogen-activated protein kinase kinase kinase 10;Inhibit
    CAS: 1229582-33-5 PubChem CID: 54764565 Formula: C27H27N5 Molecular Weight: 421.54
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥96%
    In Stock Item #: U275952
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    IUPAC Name
    3-(1H-indol-5-yl)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridine
    SMILES
    CN1CCN(CC1)CC2=CC=C(C=C2)C3=CC4=C(NC=C4C5=CC6=C(C=C5)NC=C6)N=C3
    InChIKey
    QKKIWEILHCXECO-UHFFFAOYSA-N
    InChI
    1S/C27H27N5/c1-31-10-12-32(13-11-31)18-19-2-4-20(5-3-19)23-15-24-25(17-30-27(24)29-16-23)21-6-7-26-22(14-21)8-9-28-26/h2-9,14-17,28H,10-13,18H2,1H3,(Hshow more
    Synonyms
    3-(1H-Indol-5-yl)-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-1Hpyrrolo[2,3-b]pyridine
  2. AKK1-IN-1
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    AKK1-IN-1
    CAS: 1093222-27-5 Formula: C20H13N5O Molecular Weight: 339.35
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: A412377
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    IUPAC Name
    N-[5-(4-cyanophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyridine-3-carboxamide
    SMILES
    C1=CC(=CN=C1)C(=O)NC2=CNC3=C2C=C(C=N3)C4=CC=C(C=C4)C#N
    InChIKey
    JTSLALYXYSRPGW-UHFFFAOYSA-N
    InChI
    1S/C20H13N5O/c21-9-13-3-5-14(6-4-13)16-8-17-18(12-24-19(17)23-11-16)25-20(26)15-2-1-7-22-10-15/h1-8,10-12H,(H,23,24)(H,25,26)
    Synonyms
    LKB1/AAK1 dual inhibitor; MDK-2275; MDK 2275; MDK2275 | A927453 | Pim1/AKK1-IN-1 | Q27462573 | F83701 | N-[5-(4-cyano...
  3. PF-6260933
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    PF-6260933
    CAS: 1811510-56-1 PubChem CID: 118701008 Formula: C16H13ClN4 Molecular Weight: 296.75
    10mM in DMSO
    In Stock Item #: P422224
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    IUPAC Name
    5-(6-aminopyridin-3-yl)-3-(4-chlorophenyl)pyridin-2-amine
    SMILES
    C1=CC(=CC=C1C2=C(N=CC(=C2)C3=CN=C(C=C3)N)N)Cl
    InChIKey
    KHPCIHZXOGHCLY-UHFFFAOYSA-N
    InChI
    1S/C16H13ClN4/c17-13-4-1-10(2-5-13)14-7-12(9-21-16(14)19)11-3-6-15(18)20-8-11/h1-9H,(H2,18,20)(H2,19,21)
    Synonyms
    PF-06260933[3,​3'-​Bipyridine]​-​6,​6'-​diamine,5-​(4-​chlorophenyl)​-
  4. PF-6260933
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    PF-6260933
    CAS: 1811510-56-1 PubChem CID: 118701008 Formula: C16H13ClN4 Molecular Weight: 296.75
    ≥98%
    In Stock Item #: P413486
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    Technical Identifiers
    IUPAC Name
    5-(6-aminopyridin-3-yl)-3-(4-chlorophenyl)pyridin-2-amine
    SMILES
    C1=CC(=CC=C1C2=C(N=CC(=C2)C3=CN=C(C=C3)N)N)Cl
    InChIKey
    KHPCIHZXOGHCLY-UHFFFAOYSA-N
    InChI
    1S/C16H13ClN4/c17-13-4-1-10(2-5-13)14-7-12(9-21-16(14)19)11-3-6-15(18)20-8-11/h1-9H,(H2,18,20)(H2,19,21)
    Synonyms
    PF-06260933[3,​3'-​Bipyridine]​-​6,​6'-​diamine,5-​(4-​chlorophenyl)​-
  5. URMC-099, Inhibitor of cyclin dependent kinase like 2;Inhibitor of death associated protein kinase 3;Inhibitor of fms related receptor tyrosine kinase 3;Inhibitor of leucine rich repeat kinase 2;Inhibitor of mitogen-activated protein kinase kinase kinase 10;Inhibit
    Wish List Compare
    URMC-099, Inhibitor of cyclin dependent kinase like 2;Inhibitor of death associated protein kinase 3;Inhibitor of fms related receptor tyrosine kinase 3;Inhibitor of leucine rich repeat kinase 2;Inhibitor of mitogen-activated protein kinase kinase kinase 10;Inhibit
    CAS: 1229582-33-5 PubChem CID: 54764565 Formula: C27H27N5 Molecular Weight: 421.54
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    In Stock Item #: U420995
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    Technical Identifiers
    IUPAC Name
    3-(1H-indol-5-yl)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridine
    SMILES
    CN1CCN(CC1)CC2=CC=C(C=C2)C3=CC4=C(NC=C4C5=CC6=C(C=C5)NC=C6)N=C3
    InChIKey
    QKKIWEILHCXECO-UHFFFAOYSA-N
    InChI
    1S/C27H27N5/c1-31-10-12-32(13-11-31)18-19-2-4-20(5-3-19)23-15-24-25(17-30-27(24)29-16-23)21-6-7-26-22(14-21)8-9-28-26/h2-9,14-17,28H,10-13,18H2,1H3,(Hshow more
    Synonyms
    3-(1H-Indol-5-yl)-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-1Hpyrrolo[2,3-b]pyridine
  6. no_selection
    Wish List Compare
    4-(4-Fluorobenzyl)-8-(1H-pyrrolo[2,3-b]pyridin-5-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one, Inhibitor of TRAF2 and NCK interacting kinase
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    Out of Stock Item #: F608934
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    IUPAC Name
    4-(4-Fluorobenzyl)-8-(1H-pyrrolo[2,3-b]pyridin-5-yl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one
    SMILES
    O=C1c2ccc(c3cc4cc[nH]c4nc3)cc2OCCN1Cc1ccc(F)cc1
    InChIKey
    UVLOISNMRLZTPF-UHFFFAOYSA-N
    InChI
    1S/C23H18FN3O2/c24-19-4-1-15(2-5-19)14-27-9-10-29-21-12-16(3-6-20(21)23(27)28)18-11-17-7-8-25-22(17)26-13-18/h1-8,11-13H,9-10,14H2,(H,25,26)
    Synonyms
    compound 21k
  7. no_selection
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    4-methoxy-3-[2-[3-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyridin-4-yl]benzonitrile, Inhibitor of TRAF2 and NCK interacting kinase
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    Out of Stock Item #: M609349
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    IUPAC Name
    4-methoxy-3-[2-[3-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyridin-4-yl]benzonitrile
    SMILES
    COc1cc(ccc1N1CCN(CC1)C)Nc1nccc(c1)c1cc(C#N)ccc1OC
    InChIKey
    GOMSKBLQVUFHHS-UHFFFAOYSA-N
    InChI
    1S/C25H27N5O2/c1-29-10-12-30(13-11-29)22-6-5-20(16-24(22)32-3)28-25-15-19(8-9-27-25)21-14-18(17-26)4-7-23(21)31-2/h4-9,14-16H,10-13H2,1-3H3,(H,27,28)
    Synonyms
    compound 5
  9. KY-05009
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    KY-05009
    CAS: 1228280-29-2 PubChem CID: 46234348 Formula: C18H16N4O2S Molecular Weight: 352.41
    ≥99%
    Out of Stock Item #: K651390
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    IUPAC Name
    2-anilino-5-[(4-methylbenzoyl)amino]-1,3-thiazole-4-carboxamide
    SMILES
    CC1=CC=C(C=C1)C(=O)NC2=C(N=C(S2)NC3=CC=CC=C3)C(=O)N
    InChIKey
    WCEDGRTWDSHZHF-UHFFFAOYSA-N
    InChI
    1S/C18H16N4O2S/c1-11-7-9-12(10-8-11)16(24)22-17-14(15(19)23)21-18(25-17)20-13-5-3-2-4-6-13/h2-10H,1H3,(H2,19,23)(H,20,21)(H,22,24)
  10. PD 407824
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    PD 407824
    CAS: 622864-54-4 EC Number: 663-313-7 PubChem CID: 4369491 Formula: C20H12N2O3 Molecular Weight: 328.32
    ≥99%
    Out of Stock Item #: P1426961
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    IUPAC Name
    9-hydroxy-4-phenyl-6H-pyrrolo[3,4-c]carbazole-1,3-dione
    SMILES
    C1=CC=C(C=C1)C2=CC3=C(C4=C(N3)C=CC(=C4)O)C5=C2C(=O)NC5=O
    InChIKey
    IAUZTOZLTFSMIE-UHFFFAOYSA-N
    InChI
    1S/C20H12N2O3/c23-11-6-7-14-13(8-11)16-15(21-14)9-12(10-4-2-1-3-5-10)17-18(16)20(25)22-19(17)24/h1-9,21,23H,(H,22,24,25)
  11. PD 407824
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    PD 407824
    CAS: 622864-54-4 EC Number: 663-313-7 PubChem CID: 4369491 Formula: C20H12N2O3 Molecular Weight: 328.32
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10 mM in DMSO
    Out of Stock Item #: P1498820
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  12. Pim1/AKK1-IN-1
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    Pim1/AKK1-IN-1
    CAS: 1093222-27-5 Formula: C20H13N5O Molecular Weight: 339.35
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10 mM in DMSO
    Out of Stock Item #: P1493725
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