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Tyrosine-protein kinase itk/tsk (ITK)

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  1. RepSox
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    RepSox
    CAS: 446859-33-2 EC Number: 663-924-9 Formula: C17H13N5 Molecular Weight: 287.32
    ≥98%
    In Stock Item #: R125531
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    Technical Identifiers
    IUPAC Name
    2-[5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]-1,5-naphthyridine
    SMILES
    CC1=NC(=CC=C1)C2=C(C=NN2)C3=NC4=C(C=C3)N=CC=C4
    InChIKey
    LBPKYPYHDKKRFS-UHFFFAOYSA-N
    InChI
    1S/C17H13N5/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14/h2-10H,1H3,(H,19,22)
    Synonyms
    ALK5 Inhibitor II | 2-(3-(6-methyl-2-pyridinyl)-1h-pyrazol-4-yl)-1,5-naphthyridine | DTXSID80332295 | AKOS016009677 |...
  2. AMG-458
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    AMG-458
    CAS: 913376-83-7 Formula: C30H29N5O5 Molecular Weight: 539.58
    ≥99%
    In Stock Item #: A129793
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    Technical Identifiers
    IUPAC Name
    1-(2-hydroxy-2-methylpropyl)-N-[5-(7-methoxyquinolin-4-yl)oxypyridin-2-yl]-5-methyl-3-oxo-2-phenylpyrazole-4-carboxamide
    SMILES
    CC1=C(C(=O)N(N1CC(C)(C)O)C2=CC=CC=C2)C(=O)NC3=NC=C(C=C3)OC4=C5C=CC(=CC5=NC=C4)OC
    InChIKey
    GLBZSOQDAOLMGC-UHFFFAOYSA-N
    InChI
    1S/C30H29N5O5/c1-19-27(29(37)35(20-8-6-5-7-9-20)34(19)18-30(2,3)38)28(36)33-26-13-11-22(17-32-26)40-25-14-15-31-24-16-21(39-4)10-12-23(24)25/h5-17,38Hshow more
    Synonyms
    2,3-dihydro-1-(2-hydroxy-2-methylpropyl)-N-[5-[(7-methoxy-4-quinolinyl)oxy]-2-pyridinyl]-5-methyl-3-oxo-2-phenyl-1H-P...
  3. PF 06465469
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    PF 06465469
    CAS: 1407966-77-1 EC Number: 802-699-5 PubChem CID: 71450146 Formula: C30H33N7O2 Molecular Weight: 523.63
    ≥98%
    Out of Stock Item #: P288334
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    IUPAC Name
    3-[4-amino-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]pyrazolo[3,4-d]pyrimidin-3-yl]-N-(3-methyl-4-propan-2-ylphenyl)benzamide
    SMILES
    CC1=C(C=CC(=C1)NC(=O)C2=CC=CC(=C2)C3=NN(C4=NC=NC(=C34)N)C5CCCN(C5)C(=O)C=C)C(C)C
    InChIKey
    CGJVMKJGKFEHTL-HSZRJFAPSA-N
    InChI
    1S/C30H33N7O2/c1-5-25(38)36-13-7-10-23(16-36)37-29-26(28(31)32-17-33-29)27(35-37)20-8-6-9-21(15-20)30(39)34-22-11-12-24(18(2)3)19(4)14-22/h5-6,8-9,11-show more
    Synonyms
    E98988 | HY-108691 | SCHEMBL22223727 | 1407966-77-1 | AKOS024458306 | Discontinued See A191400 | Discontinued See A19...
  4. AMG-458
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    AMG-458
    CAS: 913376-83-7 Formula: C30H29N5O5 Molecular Weight: 539.58
    10mM in DMSO
    In Stock Item #: A408812
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    Technical Identifiers
    Synonyms
    1-(2-hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin-2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyr...
  5. BMS-986142 - Moligand™, ≥99% CAS No(1643368-58-4) by Aladdin Scientific
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    BMS-986142
    CAS: 1643368-58-4 Formula: C32H30F2N4O4 Molecular Weight: 572.60
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    Out of Stock Item #: B413993
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    Technical Identifiers
    IUPAC Name
    (7S)-3-fluoro-4-[3-(8-fluoro-1-methyl-2,4-dioxoquinazolin-3-yl)-2-methylphenyl]-7-(2-hydroxypropan-2-yl)-6,7,8,9-tetrahydro-5H-carbazole-1-carboxamide
    SMILES
    CC1=C(C=CC=C1N2C(=O)C3=C(C(=CC=C3)F)N(C2=O)C)C4=C(C=C(C5=C4C6=C(N5)CC(CC6)C(C)(C)O)C(=O)N)F
    InChIKey
    ZRYMMWAJAFUANM-INIZCTEOSA-N
    InChI
    1S/C32H30F2N4O4/c1-15-17(7-6-10-24(15)38-30(40)19-8-5-9-21(33)28(19)37(4)31(38)41)25-22(34)14-20(29(35)39)27-26(25)18-12-11-16(32(2,3)42)13-23(18)36-2show more
    Synonyms
    (2S)-6-fluoro-5-[3-(8-fluoro-1-methyl-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-2-methylphenyl]-2-(2-hydroxypropan-2-...
  6. Branebrutinib (BMS-986195), Inhibitor of Bruton tyrosine kinase
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    Branebrutinib (BMS-986195), Inhibitor of Bruton tyrosine kinase
    CAS: 1912445-55-6 PubChem CID: 121293929 Formula: C20H23FN4O2 Molecular Weight: 370.42
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    Out of Stock Item #: B414208
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    IUPAC Name
    4-[(3S)-3-(but-2-ynoylamino)piperidin-1-yl]-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide
    SMILES
    CC#CC(=O)NC1CCCN(C1)C2=C(C=C(C3=C2C(=C(N3)C)C)C(=O)N)F
    InChIKey
    VJPPLCNBDLZIFG-ZDUSSCGKSA-N
    InChI
    1S/C20H23FN4O2/c1-4-6-16(26)24-13-7-5-8-25(10-13)19-15(21)9-14(20(22)27)18-17(19)11(2)12(3)23-18/h9,13,23H,5,7-8,10H2,1-3H3,(H2,22,27)(H,24,26)/t13-/mshow more
    Synonyms
    4-((3S)-3-(2-Butynoylamino)-1-piperidinyl)-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide | 4-((3S)-3-(2-BUTYNOYLAMINO...
  7. CNX-774, Inhibitor of Bruton tyrosine kinase
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    CNX-774, Inhibitor of Bruton tyrosine kinase
    CAS: 1202759-32-7 Formula: C26H22FN7O3 Molecular Weight: 499.5
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    In Stock Item #: C420894
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    Technical Identifiers
    IUPAC Name
    4-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]-N-methylpyridine-2-carboxamide
    SMILES
    CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4=CC(=CC=C4)NC(=O)C=C)F
    InChIKey
    VVLHQJDAUIPZFH-UHFFFAOYSA-N
    InChI
    1S/C26H22FN7O3/c1-3-23(35)31-17-5-4-6-18(13-17)32-24-21(27)15-30-26(34-24)33-16-7-9-19(10-8-16)37-20-11-12-29-22(14-20)25(36)28-2/h3-15H,1H2,2H3,(H,28show more
    Synonyms
    4-(4-((4-((3-acrylamidophenyl)amino)-5-fluoropyrimidin-2-yl)amino)phenoxy)-N-methylpicolinamide
  8. CNX-774, Inhibitor of Bruton tyrosine kinase
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    CNX-774, Inhibitor of Bruton tyrosine kinase
    CAS: 1202759-32-7 Formula: C26H22FN7O3 Molecular Weight: 499.5
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    In Stock Item #: C413725
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    Technical Identifiers
    IUPAC Name
    4-[4-[[5-fluoro-4-[3-(prop-2-enoylamino)anilino]pyrimidin-2-yl]amino]phenoxy]-N-methylpyridine-2-carboxamide
    SMILES
    CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4=CC(=CC=C4)NC(=O)C=C)F
    InChIKey
    VVLHQJDAUIPZFH-UHFFFAOYSA-N
    InChI
    1S/C26H22FN7O3/c1-3-23(35)31-17-5-4-6-18(13-17)32-24-21(27)15-30-26(34-24)33-16-7-9-19(10-8-16)37-20-11-12-29-22(14-20)25(36)28-2/h3-15H,1H2,2H3,(H,28show more
    Synonyms
    4-(4-((4-((3-acrylamidophenyl)amino)-5-fluoropyrimidin-2-yl)amino)phenoxy)-N-methylpicolinamide
  9. RepSox (E-616452)
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    RepSox (E-616452)
    CAS: 446859-33-2 EC Number: 663-924-9 Formula: C17H13N5 Molecular Weight: 287.32
    10mM in DMSO
    In Stock Item #: R408431
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    Pricing & Pack Sizes
    Technical Identifiers
    Synonyms
    SJN 2511,ALK5 Inhibitor II | 1,5-Naphthyridine, 2-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-
  10. Ritlecitinib (PF-06651600), TEC family kinase inhibitor
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    Ritlecitinib (PF-06651600), TEC family kinase inhibitor
    CAS: 1792180-81-4 EC Number: 815-269-7 PubChem CID: 118115473 Formula: C15H19N5O Molecular Weight: 285.34
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    In Stock Item #: R422181
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    Technical Identifiers
    IUPAC Name
    1-[(2S,5R)-2-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)piperidin-1-yl]prop-2-en-1-one
    SMILES
    C=CC(N1[C@@H](C)CC[C@@H](NC2=C3C(NC=C3)=NC=N2)C1)=O
    InChIKey
    CBRJPFGIXUFMTM-WDEREUQCSA-N
    InChI
    1S/C15H19N5O/c1-3-13(21)20-8-11(5-4-10(20)2)19-15-12-6-7-16-14(12)17-9-18-15/h3,6-7,9-11H,1,4-5,8H2,2H3,(H2,16,17,18,19)/t10-,11+/m0/s1
    Synonyms
    DB14924 | Ritlecitinib? | RITLECITINIB [WHO-DD] | PF06651600;PF 06651600 | GTPL9559 | DS-13951 | HY-100754 | AC-35550...
  11. Ritlecitinib (PF-06651600), TEC family kinase inhibitor
    Wish List Compare
    Ritlecitinib (PF-06651600), TEC family kinase inhibitor
    CAS: 1792180-81-4 EC Number: 815-269-7 PubChem CID: 118115473 Formula: C15H19N5O Molecular Weight: 285.34
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: R414045
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    Pricing & Pack Sizes
    Technical Identifiers
    IUPAC Name
    1-[(2S,5R)-2-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)piperidin-1-yl]prop-2-en-1-one
    SMILES
    C=CC(N1[C@@H](C)CC[C@@H](NC2=C3C(NC=C3)=NC=N2)C1)=O
    InChIKey
    CBRJPFGIXUFMTM-WDEREUQCSA-N
    InChI
    1S/C15H19N5O/c1-3-13(21)20-8-11(5-4-10(20)2)19-15-12-6-7-16-14(12)17-9-18-15/h3,6-7,9-11H,1,4-5,8H2,2H3,(H2,16,17,18,19)/t10-,11+/m0/s1
    Synonyms
    DB14924 | RITLECITINIB [WHO-DD] | PF06651600;PF 06651600 | GTPL9559 | DS-13951 | HY-100754 | AC-35550 | PF 06651600 |...
  12. no_selection
    Wish List Compare
    4-Amino-5-fluoro-8-(5-methoxy-1H-indazol-6-yl)quinoline-3-carboxamide, Inhibitor of BLK proto-oncogene; Src family tyrosine kinase;Inhibitor of Bruton tyrosine kinase;Inhibitor of FYN proto-oncogene; Src family tyrosine kinase;Inhibitor of IL2 inducible T cell kinase;Inhibitor of SRC proto-oncogene; non-receptor tyrosine kin
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    Out of Stock Item #: A608998
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    Technical Identifiers
    IUPAC Name
    4-Amino-5-fluoro-8-(5-methoxy-1H-indazol-6-yl)quinoline-3-carboxamide
    SMILES
    COc1cc2cn[nH]c2cc1c1ccc(c2c1ncc(c2N)C(=O)N)F
    InChIKey
    RFCJOYPMBVRHBV-UHFFFAOYSA-N
    InChI
    1S/C18H14FN5O2/c1-26-14-4-8-6-23-24-13(8)5-10(14)9-2-3-12(19)15-16(20)11(18(21)25)7-22-17(9)15/h2-7H,1H3,(H2,20,22)(H2,21,25)(H,23,24)
    Synonyms
    compound 25
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