MS0015203 - ≥98% , CAS No.73912-52-4

CAS: 73912-52-4 Cat. No.: M288855 Molecular Weight: 249.22 EC Number: 110-853-1

GRADE & PURITY ≥98%

Synonyms

F87723 | MS0015203 | SCHEMBL11227444 | AB00075034-01 | AKOS000640215 | STK894855 | 5-Methacrylamidoisophthalicacid | HY-116797 | MS-23526 | 5-[(2-methylacryloyl)amino]benzene-1,3-dicarboxylic acid | 5-[(2-Methyl-1-oxo-2-propen-1-yl)amino]-1,3-benzenedicar

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

MS15203 is a potent and selective GPR171 agonist. MS15203 increases food intake and body weight. MS15203 increases neuronal activity. MS15203 significantly increases the abundance of the mRNAs encoding proSAAS, NPY, AgRP.

Specifications

Synonyms

F87723 | MS0015203 | SCHEMBL11227444 | AB00075034-01 | AKOS000640215 | STK894855 | 5-Methacrylamidoisophthalicacid | HY-116797 | MS-23526 | 5-[(2-methylacryloyl)amino]benzene-1, 3-dicarboxylic acid | 5-[(2-Methyl-1-oxo-2-propen-1-yl)amino]-1, 3-benzenedicar

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Potent and selective GPR171 partial agonist (EC50= 90 nM; 28% inhibition of forskolin activated adenylyl cyclase activity in rat hypothalamic memebranes). Exhibits minimal binding to a panel of ~70 GPCRs and 10 other receptors (<22% of radioligand displac

Storage

Protected from light, Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Canonical Smiles: CC(=C)C(=O)NC1=CC(=CC(=C1)C(=O)O)C(=O)O
• IUPAC Name: 5-(2-methylprop-2-enoylamino)benzene-1,3-dicarboxylic acid
• InChIKey: NVOBVSWSDYFEMR-UHFFFAOYSA-N
• INCHI: 1S/C12H11NO5/c1-6(2)10(14)13-9-4-7(11(15)16)3-8(5-9)12(17)18/h3-5H,1H2,2H3,(H,13,14)(H,15,16)(H,17,18)
• Isomeric SMILES: CC(=C)C(=O)NC1=CC(=CC(=C1)C(=O)O)C(=O)O
• Molecular Weight: 249.22
• Reaxy-Rn: 5956060
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5956060&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Benzene and substituted derivatives
      • Subclass Benzoic acids and derivatives

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Benzene and substituted derivatives
• Subclass: Benzoic acids and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Acylaminobenzoic acid and derivatives
• Alternative Parents: M-phthalic acid and derivatives Benzoic acids Anilides N-arylamides Benzoyl derivatives Dicarboxylic acids and derivatives Secondary carboxylic acid amides Carboxylic acids Organopnictogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Acylaminobenzoic acid or derivatives - Meta_phthalic_acid - Benzoic acid - Anilide - Benzoyl - N-arylamide - Dicarboxylic acid or derivatives - Carboxamide group - Secondary carboxylic acid amide - Carboxylic acid derivative - Carboxylic acid - Organic nitrogen compound - Organonitrogen compound - Organooxygen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Carbonyl group - Organic oxygen compound - Aromatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as acylaminobenzoic acid and derivatives. These are derivatives of amino benzoic acid derivatives where the amine group is N-acylated.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: Solvent:DMSO, Max Conc. mg/mL: 24.92, Max Conc. mM: 100
• Sensitivity: Light sensitive
• Molecular Weight: 249.220 g/mol
• XLogP3: 1.100
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 249.064 Da
• Monoisotopic Mass: 249.064 Da
• Topological Polar Surface Area: 104.000 Ų
• Heavy Atom Count: 18
• Formal Charge: 0
• Complexity: 368.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1