Mtb ATP synthase-IN-1 - ≥98% , CAS No.2642394-38-3

CAS: 2642394-38-3 Cat. No.: M648770 Molecular Weight: 323.30

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Mtb ATP synthase-IN-1 (compound 6ab) is a potent Mycobacterium tuberculosis ( Mtb ) ATP synthase inhibitor, with MIC of 0.452-0.499 μg/mL against Mtb . Mtb ATP synthase-IN-1 has good metabolic stability, low cytotoxicity (Vero IC 50 > 64 μg/mL), and acceptable oral bioavailability. Mtb ATP synthase-IN-1 can be used for researching anti-mycobacterium

In Vivo

Mtb ATP synthase-IN-1 (50 mg/kg for PO, 5 mg/kg for IV; single dosage) exhibits good metabolic stability and acceptable oral bioavailability . Pharmacokinetic Parameters of Mtb ATP synthase-IN-1 in male CD-1 mouse . PO (50 mg/kg) IV (5 mg/kg) C max (ng/mL) 1333 1241 T max (h) 0.83 T 1/2 (h) 0.51 0.33 AUC 0-t (ng/mL·h) 2197 1667 AUC 0-∞ (ng/mL·h) 2198 1672 MRT 0-∞ (ng/mL) 1.36 0.28 CL (mL/min/kg) 51.4 F (%) 13.1 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male CD-1 mouse Dosage: 50 and 5 mg/kg Administration: 50 mg/kg for PO, 5 mg/kg for IV; single dosage (Pharmacokinetics Analysis) Result: Exhibited good metabolic stability and acceptable oral bioavailability.

Form:Solid

IC50& Target:MIC: 0.452-0.499 μg/mL ( Mtb )

Specifications

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Mtb ATP synthase-IN-1 (compound 6ab) is a potent Mycobacterium tuberculosis ( Mtb ) ATP synthase inhibitor, with MIC of 0.452-0.499 μg/mL against Mtb . Mtb ATP synthase-IN-1 has good metabolic stability, low cytotoxicity (Vero IC 50 > 64 μg/mL), and accep

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥98%

Names and Identifiers

• Molecular Weight: 323.30

Chemical and Physical Properties

• Solubility: DMSO : 125 mg/mL (386.64 mM; Need ultrasonic)