N,N,N′,N′-Tetramethyl-p-phenylenediamine - ≥99% , CAS No.100-22-1

CAS: 100-22-1 Cat. No.: I165342 Molecular Weight: 164.25 EC Number: 202-831-6

GRADE & PURITY ≥99%

Synonyms

CCRIS 4728 | FT-0629354 | Benzene, 1,4-bis(dimethylamino)- | NCGC00091150-03 | 1,4-Benzenediamine, N,N,N',N'-tetramethyl- | N,N,N',N'-Tetramethyl-p-fenylendiamin | Tox21_200617 | DTXSID5026124 | N,N,N',N'-Tetramethyl-p-phenylenediamine, 98% | N,N,N',N'-Te

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

N,N,N',N'-Tetramethyl-p-phenylenediamine is a reducing co-substrate for heme peroxidases. It is used for detection of peroxidases on polyacrylamide gels.

Specifications

Synonyms

CCRIS 4728 | FT-0629354 | Benzene, 1, 4-bis(dimethylamino)- | NCGC00091150-03 | 1, 4-Benzenediamine, N, N, N', N'-tetramethyl- | N, N, N', N'-Tetramethyl-p-fenylendiamin | Tox21_200617 | DTXSID5026124 | N, N, N', N'-Tetramethyl-p-phenylenediamine, 98% | N, N, N', N'-Te

Specifications & Purity

≥99%

Storage

Protected from light, Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥99%

Names and Identifiers

• Pubchem Sid: 504751360
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504751360
• Canonical Smiles: CN(C)C1=CC=C(C=C1)N(C)C
• IUPAC Name: 1-N,1-N,4-N,4-N-tetramethylbenzene-1,4-diamine
• InChIKey: CJAOGUFAAWZWNI-UHFFFAOYSA-N
• INCHI: 1S/C10H16N2/c1-11(2)9-5-7-10(8-6-9)12(3)4/h5-8H,1-4H3
• Isomeric SMILES: CN(C)C1=CC=C(C=C1)N(C)C
• WGK Germany: 1
• RTECS: ST4200000
• Molecular Weight: 164.25
• Reaxy-Rn: 1564025
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1564025&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic nitrogen compounds
    • Class Organonitrogen compounds
      • Subclass Amines
        • Level5 Tertiary amines
          • Level6 Tertiary alkylarylamines
            • Level7 Dialkylarylamines

• Kingdom: Organic compounds
• Superclass: Organic nitrogen compounds
• Class: Organonitrogen compounds
• Subclass: Amines
• Intermediate Tree Nodes: Tertiary amines - Tertiary alkylarylamines
• Direct Parent: Dialkylarylamines
• Alternative Parents: Aniline and substituted anilines Organopnictogen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Aniline or substituted anilines - Dialkylarylamine - Benzenoid - Monocyclic benzene moiety - Organopnictogen compound - Hydrocarbon derivative - Aromatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as dialkylarylamines. These are aliphatic aromatic amines in which the amino group is linked to two aliphatic chains and one aromatic group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

AR Tclin Androgen Receptor (11781 Activities)

Discover Target: AR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)

Discover Target: TSHR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CXCL8 Tchem Interleukin-8 (642 Activities)

Discover Target: CXCL8

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)

Discover Target: ALDH1A1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NR1H4 Tclin Bile acid receptor FXR (6228 Activities)

Discover Target: NR1H4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALOX15 Tchem Arachidonate 15-lipoxygenase (7108 Activities)

Discover Target: ALOX15

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Lymphoblastoid cell (5959 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 Activities)

Discover Target: HSD17B10

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)

Discover Target: APEX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

Discover Target: Nfe2l2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rorc Nuclear receptor ROR-gamma (89407 Activities)

Discover Target: Rorc

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Impa1 Inositol monophosphatase 1 (16203 Activities)

Discover Target: Impa1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Nr1i2 Nuclear receptor subfamily 1 group I member 2 (14 Activities)

Discover Target: Nr1i2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Slightly soluble in cold, more in hot water.
• Sensitivity: air & light sensitive
• Flash Point(°F): 230 °F
• Flash Point(°C): 110 °C
• Boil Point(°C): 260℃
• Melt Point(°C): 48-52℃
• Molecular Weight: 164.250 g/mol
• XLogP3: 2.600
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 164.131 Da
• Monoisotopic Mass: 164.131 Da
• Topological Polar Surface Area: 6.500 Ų
• Heavy Atom Count: 12
• Formal Charge: 0
• Complexity: 108.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Qian Liu, Junjie Liu, Peiyu Jia, Tian Yu, Ning Qi, Wei Zhou, Nanwen Li, Zhiquan Chen.  (2023)  Tunable Free Volume Structure on the Gas Separation Performance of Thermally Rearranged Poly(benzoxazole-co-imide) Membranes Studied by Positron Annihilation.  ACS Applied Polymer Materials,      [PMID:] [10.1021/acsapm.3c01737]

2. Jie Mao, Tong Wu, Zhenbin Tang, Long Xia, Liu He, Birong Zeng, Yiting Xu, Conghui Yuan, Lizong Dai.  (2022)  Molecular Exchange of Dynamic Imine Bond for the Etching of Polymer Particles.  MACROMOLECULAR RAPID COMMUNICATIONS,  43  (23): (2200562).  [PMID:35926186] [10.1002/marc.202200562]

3. Wantian Yang, Xinglin Xiao, Mingkai Li, Jiarui Hu, Xingfu Xiao, Guoliang Tong, Junnian Chen, Yunbin He.  (2021)  Conjugated Ditertiary Ammonium Templated (100)-Oriented 2D Perovskite with Efficient Broad-Band Emission.  CHEMISTRY OF MATERIALS,      [PMID:] [10.1021/acs.chemmater.1c00624]

4. Yi Luo, Riji Qiu, Xingran Zhang, Fang Li.  (2024)  Biofouling behaviors of reverse osmosis membrane in the presence of trace plasticizer for circulating cooling water treatment: Characteristics and mechanisms.  WATER RESEARCH,      [PMID:38878313] [10.1016/j.watres.2024.121937]

5. Mengxue Zhou, Zihao Wang, Mengyu Li, Qi Chen, Shengmin Zhang, Jianglin Wang.  (2024)  Passivated hydrogel interface: Armor against foreign body response and inflammation in small-diameter vascular grafts.  BIOMATERIALS,      [PMID:39724767] [10.1016/j.biomaterials.2024.123010]

6. Gao Peng, Lu Xie-Feng, Yao Ling, Xu Yuan-Jia, Zhang Shu-Yi, Liu Guo-Hong, Zhou Shun-Gui.  (2025)  Two Novel Species of Paenibacillus praedii sp. nov. and Ectobacillus soil sp. nov..  CURRENT MICROBIOLOGY,  83  (2): (112).  [PMID:41460291] [10.1007/s00284-025-04697-x]