N-Succinimidyl Iodoacetate - ≥95% , CAS No.39028-27-8

CAS: 39028-27-8 Cat. No.: N133327 Molecular Weight: 283.02 EC Number: 636-792-5

GRADE & PURITY ≥95%

Synonyms

AKOS022185049 | AMY27294 | 2,5-Dioxopyrrolidin-1-yl 2-iodoacetate | (2,5-dioxopyrrolidin-1-yl) 2-iodoacetate | MFCD00058451 | A6557 | DTXSID40391202 | AS-63595 | iodoacetic acid, succinimidyl ester | N-Succinimidyl Iodoacetate | BP-22653 | N-Iodoacetoxysu

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

An amine and sulfhydryl reactive crosslinker, 1.5 angstrom spacer arm.

application：

A heterobifunctional cross-linking reagent with amine and sulfhydryl reactivity. Typically, coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5) Second coupling specific for molecules containing free sulfydryl by thioether linkage buffered at pH 7.5 (7.0-8.0). Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates. Provides a 2-atom linker.

Specifications

Synonyms

AKOS022185049 | AMY27294 | 2, 5-Dioxopyrrolidin-1-yl 2-iodoacetate | (2, 5-dioxopyrrolidin-1-yl) 2-iodoacetate | MFCD00058451 | A6557 | DTXSID40391202 | AS-63595 | iodoacetic acid, succinimidyl ester | N-Succinimidyl Iodoacetate | BP-22653 | N-Iodoacetoxysu

Specifications & Purity

≥95%

Storage

Protected from light, Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥95%

Names and Identifiers

• Canonical Smiles: C1CC(=O)N(C1=O)OC(=O)CI
• IUPAC Name: (2,5-dioxopyrrolidin-1-yl) 2-iodoacetate
• InChIKey: VRDGQQTWSGDXCU-UHFFFAOYSA-N
• INCHI: 1S/C6H6INO4/c7-3-6(11)12-8-4(9)1-2-5(8)10/h1-3H2
• Isomeric SMILES: C1CC(=O)N(C1=O)OC(=O)CI
• WGK Germany: 3
• Molecular Weight: 283.02
• Reaxy-Rn: 1213727
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1213727&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Pyrrolidines
      • Subclass Pyrrolidones

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Pyrrolidines
• Subclass: Pyrrolidones
• Intermediate Tree Nodes: Not available
• Direct Parent: Pyrrolidine-2-ones
• Alternative Parents: Dicarboximides Alpha-halocarboxylic acid derivatives Lactams Carboxylic acid salts Monocarboxylic acids and derivatives Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organoiodides Organic salts Organic oxides Hydrocarbon derivatives Carbonyl compounds Alkyl iodides
• Molecular Framework: Aliphatic heteromonocyclic compounds
• Substituents: 2-pyrrolidone - Alpha-halocarboxylic acid derivative - Alpha-halocarboxylic acid or derivatives - Dicarboximide - Carboxylic acid salt - Lactam - Carboxylic acid derivative - Azacycle - Monocarboxylic acid or derivatives - Alkyl halide - Organonitrogen compound - Organoiodide - Organohalogen compound - Organooxygen compound - Organic salt - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Carbonyl group - Organic oxygen compound - Organic nitrogen compound - Alkyl iodide - Aliphatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as pyrrolidine-2-ones. These are pyrrolidines which bear a C=O group at position 2 of the pyrrolidine ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: Soluble in Chloroform, Dichloromethane and Ethyl Acetate
• Sensitivity: Heat & Moisture & Light Sensitive
• Melt Point(°C): 146.0 to 150.0 °C
• Molecular Weight: 283.020 g/mol
• XLogP3: -0.100
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 282.934 Da
• Monoisotopic Mass: 282.934 Da
• Topological Polar Surface Area: 63.700 Ų
• Heavy Atom Count: 12
• Formal Charge: 0
• Complexity: 224.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1