Novobiocin Sodium - ≥95% , CAS No.1476-53-5

CAS: 1476-53-5 Cat. No.: N129248 Molecular Weight: 634.61 Beilstein Registry Number: 3892910 EC Number: 216-023-6 PubChem CID: 54730021

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Novobiocin Sodium - ≥95% CAS No(1476-53-5) N129248 by Aladdin Scientific

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AVAILABLE TO ORDER

GRADE & PURITY ≥95%

Synonyms

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview Specifications Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solution Calculators Reviews

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Why this grade

≥95% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Protected from light,Store at -20°C,Argon charged Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Novobiocin Sodium is a very potent bacterial DNA gyrase and human organic anion transporters with Ki of 14.87 ± 0.40 μM for hOAT1, 4.77 ± 1.12 μM for hOAT3 and 90.50 ± 7.50 μM for hOAT4.
An Hsp90 and DNA gyrase inhibitor.

Novobiocin sodium salt is an antibiotic derived from soil bacteria. Novobiocin inhibits the action of bacterial DNA gyrase and belongs to a class of compounds called coumarin antibiotics. Coumarins are heterocyclic compounds with a wide range of biological activity, including antibacterial, anticoagulant, antioxidant, anti-inflammatory, antiviral, antitumor, and enzyme inhibitory effects.

Application

For the production of positively supercoiled plasmid DNA. Inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. Inhibitor of retrovirus RNA-dependent DNA-polymerase.
Novobiocin Sodium Salt, an inhibitor of Hsp90, can be used:
in the research heat shock protein inhibition and to produce positively supercoiled plasmid DNA
in the research on the efficacy of probiotics
in the research on the efficacy of human monocytes and dendritic cells for T-cell replication

Specifications

Synonyms

Specifications & Purity

≥95%

Biochemical and Physiological Mechanisms

Mode of Action: Inhibits DNA synthesis by inhibiting the enzyme Topoisomerase II. Antimicrobial spectrum: Gram-positive bacterial. Novobiocin inhibits DNA synthesis by inhibiting the GyrB subunit of the Topoisomerase enzyme involved in energy transduction

Storage

Protected from light, Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥95%

Names and Identifiers

Pubchem Sid	504771387
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504771387
Canonical Smiles	CC1=C(C=CC2=C1OC(=O)C(=C2O)NC(=O)C3=CC(=C(C=C3)[O-])CC=C(C)C)OC4C(C(C(C(O4)(C)C)OC)OC(=O)N)O.[Na+]
IUPAC Name	sodium;4-[[7-(4-carbamoyloxy-3-hydroxy-5-methoxy-6,6-dimethyloxan-2-yl)oxy-4-hydroxy-8-methyl-2-oxochromen-3-yl]carbamoyl]-2-(3-methylbut-2-enyl)phenolate
InChIKey	WWPRGAYLRGSOSU-UHFFFAOYSA-M
INCHI	1S/C31H36N2O11.Na/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29;/h7,9-13,23,25-26,29,34-36H,8H2,1-6H3,(H2,32,39)(H,33,37);/q;+1/p-1
Isomeric SMILES	CC1=C(C=CC2=C1OC(=O)C(=C2O)NC(=O)C3=CC(=C(C=C3)[O-])CC=C(C)C)OC4C(C(C(C(O4)(C)C)OC)OC(=O)N)O.[Na+]
WGK Germany	2
RTECS	RD5425000
PubChem CID	54730021
Molecular Weight	634.61
Beilstein	3892910

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Phenylpropanoids and polyketides
  - Class Coumarins and derivatives
    - Subclass Coumarin glycosides

Kingdom	Organic compounds
Superclass	Phenylpropanoids and polyketides
Class	Coumarins and derivatives
Subclass	Coumarin glycosides
Intermediate Tree Nodes	Not available
Direct Parent	Coumarin glycosides
Alternative Parents	Phenolic glycosides 4-hydroxycoumarins Hexoses O-glycosyl compounds 1-benzopyrans Benzamides Benzoyl derivatives Pyranones and derivatives Phenoxides Oxanes Heteroaromatic compounds Vinylogous acids Lactones Secondary alcohols Secondary carboxylic acid amides Oxacyclic compounds Dialkyl ethers Carboximidic acids and derivatives Acetals Organic sodium salts Organic oxides Organopnictogen compounds Imines Hydrocarbon derivatives Organic zwitterions
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Coumarin o-glycoside - Coumarin-7-o-glycoside - Phenolic glycoside - 4-hydroxycoumarin - Hydroxycoumarin - Hexose monosaccharide - O-glycosyl compound - Glycosyl compound - 1-benzopyran - Benzopyran - Benzamide - Benzoic acid or derivatives - Benzoyl - Phenoxide - Pyranone - Benzenoid - Monocyclic benzene moiety - Monosaccharide - Oxane - Pyran - Vinylogous acid - Heteroaromatic compound - Lactone - Secondary carboxylic acid amide - Secondary alcohol - Carboxamide group - Acetal - Carboximidic acid derivative - Organoheterocyclic compound - Organic alkali metal salt - Dialkyl ether - Ether - Carboxylic acid derivative - Oxacycle - Organic nitrogen compound - Imine - Organonitrogen compound - Organooxygen compound - Organic zwitterion - Organic salt - Organic sodium salt - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Alcohol - Organic oxygen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as coumarin glycosides. These are aromatic compounds containing a carbohydrate moiety glycosidically bound to a coumarin moiety.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(Human)

A498 (42825 Activities)

Lot Number	Certificate Type	Date	Item
F2612593	Certificate of Analysis	Jun 02, 2026	N129248
F2610325	Certificate of Analysis	Jun 02, 2026	N129248
F2610313	Certificate of Analysis	Jun 02, 2026	N129248
G2221429	Certificate of Analysis	Mar 13, 2026	N129248
G2221432	Certificate of Analysis	Feb 04, 2026	N129248
G2221431	Certificate of Analysis	Feb 04, 2026	N129248
G2221430	Certificate of Analysis	Feb 04, 2026	N129248
C2405568	Certificate of Analysis	Dec 12, 2025	N129248
H2526627	Certificate of Analysis	Aug 21, 2025	N129248
E2618129	Certificate of Analysis	Aug 21, 2025	N129248
H2526628	Certificate of Analysis	Aug 21, 2025	N129248
H2526629	Certificate of Analysis	Aug 21, 2025	N129248
A2606030	Certificate of Analysis	Aug 21, 2025	N129248
H2526632	Certificate of Analysis	Aug 21, 2025	N129248
H2526640	Certificate of Analysis	Aug 21, 2025	N129248
H2526633	Certificate of Analysis	Aug 21, 2025	N129248
H2526634	Certificate of Analysis	Aug 21, 2025	N129248
A2212328	Certificate of Analysis	Jul 15, 2025	N129248
C2405571	Certificate of Analysis	Jan 30, 2024	N129248
C2405570	Certificate of Analysis	Jan 30, 2024	N129248
C2405569	Certificate of Analysis	Jan 30, 2024	N129248
A2212477	Certificate of Analysis	Dec 24, 2021	N129248
A2212465	Certificate of Analysis	Dec 24, 2021	N129248
A2212464	Certificate of Analysis	Dec 24, 2021	N129248

Solubility	DMSO 127 mg/mL Water 127 mg/mL Ethanol 127 mg/mL
Sensitivity	Light sensitive；Moisture sensitive
Melt Point(°C)	215°C
Molecular Weight	634.600 g/mol
XLogP3
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	9
Exact Mass	634.214 Da
Monoisotopic Mass	634.214 Da
Topological Polar Surface Area	199.000 Å²
Heavy Atom Count	45
Formal Charge	0
Complexity	1160.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	4
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

Novobiocin Sodium - ≥95% , CAS No.1476-53-5

Why this grade

Storage & shipping

Quality documents

Literature proof

Overview

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

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