O-Phosphorylethanolamine - ≥98%(N)(T) , CAS No.1071-23-4

CAS: 1071-23-4 Cat. No.: O160016 Molecular Weight: 141.06 EC Number: 213-988-5

GRADE & PURITY ≥98%(N)(T)

Synonyms

Ethanol, 2-amino-, dihydrogen phosphate (ester) | O-Phosphorylethanolamine | Ethanol, 2-amino-, phosphate | NSC 254167 | NSC254167 | NSC-254167 | 2-AMINOETHYL PHOSPHATE | AKOS005256383 | Ethanol, phosphate | P0503_SIGMA | s6483 | WLN: Z2OPQQO | (2-aminoet

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

Synonyms

Ethanol, 2-amino-, dihydrogen phosphate (ester) | O-Phosphorylethanolamine | Ethanol, 2-amino-, phosphate | NSC 254167 | NSC254167 | NSC-254167 | 2-AMINOETHYL PHOSPHATE | AKOS005256383 | Ethanol, phosphate | P0503_SIGMA | s6483 | WLN: Z2OPQQO | (2-aminoet

Specifications & Purity

≥98%(N)(T)

Biochemical and Physiological Mechanisms

Phosphorylethanolamine participates in phospholipid metabolism. Its release can be stimulated occasionally by depolarizing stimuli. Reduction of phosphorylethanolamine levels has been observed in Alzheimer′s and Huntington′s disease.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%(N)(T)

Names and Identifiers

• Pubchem Sid: 488179589
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488179589
• Canonical Smiles: C(COP(=O)(O)O)N
• IUPAC Name: 2-aminoethyl dihydrogen phosphate
• InChIKey: SUHOOTKUPISOBE-UHFFFAOYSA-N
• INCHI: 1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)
• Isomeric SMILES: C(COP(=O)(O)O)N
• RTECS: KJ5830000
• Molecular Weight: 141.06
• Reaxy-Rn: 1758916
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1758916&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Organic phosphoric acids and derivatives
      • Subclass Phosphate esters

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Organic phosphoric acids and derivatives
• Subclass: Phosphate esters
• Intermediate Tree Nodes: Not available
• Direct Parent: Phosphoethanolamines
• Alternative Parents: Monoalkyl phosphates Organopnictogen compounds Organooxygen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Phosphoethanolamine - Monoalkyl phosphate - Alkyl phosphate - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Primary amine - Organooxygen compound - Organonitrogen compound - Primary aliphatic amine - Amine - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as phosphoethanolamines. These are compounds containing a phosphate linked to the second carbon of an ethanolamine.
• External Descriptors: primary amino compound - phosphoethanolamine

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

APCS Tchem Serum amyloid P-component (232 Activities)

Discover Target: APCS

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Solubility in water: soluble.
• Melt Point(°C): 242.3℃
• Molecular Weight: 141.060 g/mol
• XLogP3: -4.800
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 141.019 Da
• Monoisotopic Mass: 141.019 Da
• Topological Polar Surface Area: 92.800 Ų
• Heavy Atom Count: 8
• Formal Charge: 0
• Complexity: 98.200
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Lei Yang, Yuese Chen, Ting Zhang, Heqing Fu.  (2023)  Superior anti-smudge and flame retardancy of polydimethylsiloxane composite coating with phosphorus modified CO0.5Ni0.5Fe2O4.  JOURNAL OF APPLIED POLYMER SCIENCE,  140  (19): (e53832).  [PMID:] [10.1002/app.53832]

2. Lin Wu, Yunchao Wu, Liu Jingjin, Suwan Liu, Qianzhe Li, Mengyu Yang, Miaomiao Zhang, Qing Ji, Feimin Zhang, Fengyi Du.  (2022)  Calcium and phosphorus co-doped carbon dots enhance osteogenic differentiation for calvarial defect repair in situ.  Biomedical Materials,  17  (5): (055007).  [PMID:35835088] [10.1088/1748-605X/ac812f]

3. Weisu Kong, Da Zhu, Rengan Luo, Siqi Yu, Huangxian Ju.  (2022)  Framework-promoted charge transfer for highly selective photoelectrochemical biosensing of dopamine.  BIOSENSORS & BIOELECTRONICS,      [PMID:35594626] [10.1016/j.bios.2022.114369]

4. Zhongshan Chen, Xuan He, Qian Li, Hui Yang, Yang Liu, Lining Wu, Zhixin Liu, Baowei Hu, Xiangke Wang.  (2022)  Low-temperature plasma induced phosphate groups onto coffee residue-derived porous carbon for efficient U(VI) extraction.  Journal of Environmental Sciences,      [PMID:35717075] [10.1016/j.jes.2021.10.003]

5. Liu Wenqian, Wang Qing, Zhang Ruoyan, Liu Mengshuang, Wang Cuicui, Liu Zixi, Xiang Chenggang, Lu Xiaohong, Zhang Xiaojing, Li Xiaojun, Wang Tao, Gao Lihong, Zhang Wenna.  (2022)  Rootstock–scion exchanging mRNAs participate in the pathways of amino acid and fatty acid metabolism in cucumber under early chilling stress.  Horticulture Research,      [PMID:35184197] [10.1093/hr/uhac031]

6. Hua-Rui Nan, Yun-Hai Liu, Wen-Juan Gong, Hong-Bo Peng, You-Qun Wang, Zhi-Bin Zhang, Xiao-Hong Cao.  (2022)  An inner-filter-effect based ratiometric fluorescent sensor for the detection of uranyl ions in real samples.  Analytical Methods,  14  (5): (532-540).  [PMID:35043798] [10.1039/D1AY02017J]

7. Xuejia Chen, Tingkai Xiong, Jin Xu, Yan Li, Min Zhang, Ying Liang.  (2021)  Determination of ammonium in natural water using a quinoline-based o-dialdehyde fluorescent reagent with visible excitation wavelength.  Analytical Methods,  13  (43): (5231-5239).  [PMID:34704564] [10.1039/D1AY01462E]

8. Yu Xiao-Feng, Liu Yun-Hai, Zhou Zhi-Wei, Xiong Guo-Xuan, Cao Xiao-Hong, Li Min, Zhang Zhi-Bin.  (2014)  Adsorptive removal of U(VI) from aqueous solution by hydrothermal carbon spheres with phosphate group.  JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,  300  (3): (1235-1244).  [PMID:] [10.1007/s10967-014-3081-6]

9. Shuang Shen, Shuli Nong, Xianpeng Zhang, Jiaqi Song, Caiting Meng, Xinling Liu, Liang Shao, Guanying Li, Li Xu.  (2024)  An ALP-responsive, anionic iridium complex for specific recognition of osteosarcoma cells.  DALTON TRANSACTIONS,      [PMID:38695060] [10.1039/D4DT00568F]

10. He Liangrui, Wang Liyang, Yu Xujiang, Tang Yizhang, Jiang Zhao, Yang Guoliang, Liu Zhuang, Li Wanwan.  (2024)  Full-course NIR-II imaging-navigated fractionated photodynamic therapy of bladder tumours with X-ray-activated nanotransducers.  Nature Communications,  15  (1): (1-19).  [PMID:39300124] [10.1038/s41467-024-52607-9]

11. Xiang-Bo Zeng, Xue-Chen Pei, De-Yang Li, Fa-Wen Yin, Hui-Lin Liu, Meng-Ling Jin, Jiang-Hua Zhang, Da-Yong Zhou.  (2024)  Mechanism of discoloration of Antarctic krill oil upon storage: A study based on model systems.  FOOD CHEMISTRY,      [PMID:39002334] [10.1016/j.foodchem.2024.140376]

12. Chengyu Sun, Yihao Ji, Wenyan Huang, Fuli Deng, Yi Zhang.  (2025)  Simultaneous defect engineering and phosphoric acid functionalization of UiO-66 for enhanced adsorption of Yb(III).  CHEMICAL ENGINEERING SCIENCE,      [PMID:] [10.1016/j.ces.2025.122638]

13. Zhihao Zhang, Feng Liu, Xin Lan, Fuhai Wang, Jiahao Sun, Honglong Wei.  (2024)  Pyroptosis-related genes features on prediction of the prognosis in liver cancer: An integrated analysis of bulk and single-cell RNA sequencing.  Heliyon,      [PMID:39416843] [10.1016/j.heliyon.2024.e38438]

14. Chuanwei Zhou, Chenyu Liu, Dongyong Sha, Lili Sun, Changsheng Liu, Yuan Yuan.  (2025)  Homogeneous “Hard-Soft” Biphasic Bone Adhesives Promote Comminuted Fracture Healing through Interfacial Adaptation and Mechanical Property Maintenance.  ADVANCED MATERIALS,      [PMID:40511692] [10.1002/adma.202502598]

15. Chen Xue, Wang Chenyang, Li Mao, Zhang Dexiu, Wei Yinmao.  (2025)  Preparation of polydentate phosphonate-functionalized adsorbent for selective extraction of rare earth ions in harsh acidic solution.  MICROCHIMICA ACTA,  192  (5): (1-12).  [PMID:40240705] [10.1007/s00604-025-07162-5]