Oltipraz - ≥98% , CAS No.64224-21-1

CAS: 64224-21-1 Cat. No.: O136690 Molecular Weight: 226.34 EC Number: 264-736-6

1 Citations COA

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Oltipraz - ≥98% CAS No(64224-21-1) by Aladdin Scientific

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AVAILABLE TO ORDER

GRADE & PURITY ≥98%

Synonyms

BCP16064 | RP 35972;NSC 347901 | BRN 0978110 | DTXSID7021079 | NSC347901 | NSC-347901 | Q7088765 | 4-methyl-5-(pyrazin-2-yl)-3H-1,2-dithiole-3-thione | A13164 | NSC759840 | NSC-759840 | MFCD00868499 | SR-05000001517-1 | AB01275510_02 | C8H6N2S3 | SMR00155

Storage

Store at 2-8°C,Protected from light,Argon charged

Shipped In

Wet ice

Overview Specifications Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Documents & Articles Citations of This Product References Solution Calculators Reviews

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Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at 2-8°C,Protected from light,Argon charged Ships Wet ice Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 1 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Oltipraz has an inhibitory effect on HIF-1α activation by insulin in a time-dependent manner, completely abrogating HIF-1α induction at ≥10 μM concentrations, the IC50 of Oltipraz for HIF-1α inhibition is 10 μM.
Oltipraz is a potent Nrf2 activator and a potent inducer of Phase II detoxification enzymes, most notably glutathione-S-transferase (GST).

Specifications

Synonyms

BCP16064 | RP 35972;NSC 347901 | BRN 0978110 | DTXSID7021079 | NSC347901 | NSC-347901 | Q7088765 | 4-methyl-5-(pyrazin-2-yl)-3H-1, 2-dithiole-3-thione | A13164 | NSC759840 | NSC-759840 | MFCD00868499 | SR-05000001517-1 | AB01275510_02 | C8H6N2S3 | SMR00155

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Oltipraz is an activator of Nrf2. Nrf2 (NF-E2-related factor 2) is a transcription factor that binds to antioxidant response elements (AREs) and activates these genes. Oltipraz activates Nrf2 and subsequently elevates expression of the detoxification gene

Storage

Store at 2-8°C, Protected from light, Argon charged

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥98%

Names and Identifiers

Pubchem Sid	504753641
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504753641
Canonical Smiles	CC1=C(SSC1=S)C2=NC=CN=C2
IUPAC Name	4-methyl-5-pyrazin-2-yldithiole-3-thione
InChIKey	CKNAQFVBEHDJQV-UHFFFAOYSA-N
INCHI	1S/C8H6N2S3/c1-5-7(12-13-8(5)11)6-4-9-2-3-10-6/h2-4H,1H3
Isomeric SMILES	CC1=C(SSC1=S)C2=NC=CN=C2
WGK Germany	3
RTECS	JP1293000
Molecular Weight	226.34
Reaxy-Rn	978110
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=978110&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Diazines
    - Subclass Pyrazines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Diazines
Subclass	Pyrazines
Intermediate Tree Nodes	Not available
Direct Parent	Pyrazines
Alternative Parents	1,2-dithiole-3-thiones Heteroaromatic compounds Azacyclic compounds Organosulfur compounds Organopnictogen compounds Organonitrogen compounds Hydrocarbon derivatives
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	1,2-dithiole-3-thione - Pyrazine - Heteroaromatic compound - Dithiole - 1,2-dithiole - Azacycle - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Organosulfur compound - Organonitrogen compound - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as pyrazines. These are compounds containing a pyrazine ring, which is a six-member aromatic heterocycle, that consists of two nitrogen atoms (at positions 1 and 4) and four carbon atoms.
External Descriptors	pyrazines - 1,2-dithiole
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(Human)

PTPN11 Tchem Protein-tyrosine phosphatase 2C (2297 Activities)

Discover Target: PTPN11

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)

Discover Target: CYP1A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NQO1 Tchem Quinone reductase 1 (1746 Activities)

Discover Target: NQO1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A498 (42825 Activities)

Lot Number	Certificate Type	Date	Item
I2226008	Certificate of Analysis	Apr 03, 2026	O136690
I2226009	Certificate of Analysis	Apr 03, 2026	O136690
G23181123	Certificate of Analysis	May 09, 2025	O136690
G23181126	Certificate of Analysis	May 09, 2025	O136690
G23181145	Certificate of Analysis	May 09, 2025	O136690
G23181148	Certificate of Analysis	May 09, 2025	O136690
G23181149	Certificate of Analysis	May 09, 2025	O136690
G23181151	Certificate of Analysis	May 09, 2025	O136690
G23181159	Certificate of Analysis	May 09, 2025	O136690
G23181160	Certificate of Analysis	May 09, 2025	O136690
F1702008	Certificate of Analysis	Oct 15, 2024	O136690
I2226010	Certificate of Analysis	Jul 11, 2022	O136690

Solubility	Soluble in methanol, and DMSO ( >20 mg/ml)., Soluble in methanol, and DMSO ( >20 mg/ml).
Sensitivity	light & heat & air sensitive
Refractive Index	1.76
Melt Point(°C)	165-166°C
Molecular Weight	226.300 g/mol
XLogP3	1.100
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	1
Exact Mass	225.969 Da
Monoisotopic Mass	225.969 Da
Topological Polar Surface Area	108.000 Å²
Heavy Atom Count	13
Formal Charge	0
Complexity	262.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Oltipraz - ≥98% , CAS No.64224-21-1

Why this grade

Storage & shipping

Quality documents

Literature proof

Overview

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

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