PAD2-IN-1 hydrochloride - ≥99% , CAS No.P658847

CAS: P658847 Cat. No.: P658847 Molecular Weight: 517

GRADE & PURITY ≥99%

Storage

Store at 2-8°C,Protected from light,Desiccated

Shipped In

Wet ice

Overview

PAD2-IN-1 hydrochloride, a benzimidazole-based derivative, is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. PAD2-IN-1 hydrochloride shows superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold).

Appearance:Solid

IC50& Target:Protein Arginine Deiminase 2 (PAD2)

In Vitro:In the target engagement assay, the EC 50 of PAD2-IN-1 (compound 32a) hydrochloride is 8.3 μM in HEK293T/PAD2 cells, the enhanced potency of PAD2-IN-1 overcomes its relatively poor ability to enter cells. PAD2-IN-1 (compound 32a; 1-25 μM) hydrochlori

Biological Activity:AFM32a (PAD2-IN-1) hydrochloride, a benzimidazole-based derivative, is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. AFM32a hydrochloride shows superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold).

Specifications

Specifications & Purity

≥99%

Storage

Store at 2-8°C, Protected from light, Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥99%

Names and Identifiers

• Canonical Smiles: O=C(C1=CC=CC(CN2)=C1C2=O)N[C@H](C3=NC4=C(OCC)C=CC=C4N3C)CCCNC(CF)=N.[H]Cl
• Molecular Weight: 517

Chemical and Physical Properties

• Solubility: DMSO : 100 mg/mL (193.42 mM; Need ultrasonic)