PIKfyve-IN-1 - ≥95% , CAS No.2857982-26-2

CAS: 2857982-26-2 Cat. No.: P650468 Molecular Weight: 331.41 EC Number: 101-535-3

GRADE & PURITY ≥95%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

PIKfyve-IN-1 is a highly potent and cell-active chemical probe that inhibits phosphatidylinositol-3phosphate 5-kinase (PIKfyve) with IC 50 value of 6.9 nM. PIKfyve-IN-1 can be used for the research of PIKfyve in virology

In Vitro

PIKfyve-IN-1 inhibits PIKfyve in PIKfyve enzymatic assay and PIKfyve NanoBRET assay with IC 50 values of 6.9 nM and 4.01 nM, respectively. PIKfyve-IN-1 (0-10 μM) disrupts multiple phases of the lifecycle of coronaviruses: viral replication and viral entry. PIKfyve-IN-1 inhibits MHV replication and SARS-CoV-2 replication with IC 50 values of 23.5 nM and 19.5 nM, respectively. PIKfyve-IN-1 (5 μM) impacts lysosomal homeostasis. MCE has not independently confirmed the accuracy of these methods. They are for reference only. ImmunofluorescenceCell Line: Calu-3 cells Concentration: 1 μM Incubation Time: 1 h Result: Inhibited the uptake of lentivirus pseudotyped with the SARS-CoV-2 spike glycoprotein.

Form:Solid

IC50& Target:IC50: 6.9 nM (PIKfyve)

Specifications

Specifications & Purity

≥95%

Biochemical and Physiological Mechanisms

PIKfyve-IN-1 is a highly potent and cell-active chemical probe that inhibits phosphatidylinositol-3phosphate 5-kinase (PIKfyve) with IC 50 value of 6.9 nM. PIKfyve-IN-1 can be used for the research of PIKfyve in virology.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥95%

Names and Identifiers

• Molecular Weight: 331.41