Pirmenol hydrochloride - ≥99% , CAS No.61477-94-9

CAS: 61477-94-9 Cat. No.: P649950 Molecular Weight: 374.95 PubChem CID: 65501

GRADE & PURITY ≥99%

Storage

Store at 2-8°C

Shipped In

Wet ice

Overview

Pirmenol ((±)-Pirmenol) hydrochloride is an orally active antiarrhythmic agent. Pirmenol hydrochloride inhibits I K.ACh ( IC 50 : 0.1 μM) by blocking mAchR . Pirmenol hydrochloride can be used in the research of cardiovascular disease , such as atrial fibrillation.

In Vitro

Pirmenol (1 μM) hydrochloride inhibits the I K.ACh induced by carbachol or intracellular loading of GTPg S in in atrial cells. Pirmenol (5 μM) hydrochloride depresses the early part of the plateau and lengthened the final repolarization of the action potentials in ventricular myocytes. Pirmenol (1 μM) hydrochloride prolongs the action potential duration at 90% repolarization in atrial muscles and Purkinje fibers. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pirmenol (2.5 and 5 mg/kg, p.o.) hydrochloride is effective against the arrhythmias in conscious, coronary artery ligated dogs. Pirmenol (rats) hydrochloride shows LD 50 s of 359.9 mg/kg (p.o), 23.6 mg/kg (i.v.). Pirmenol (mice) hydrochloride shows LD 50 s of 215.5 mg/kg (p.o), 20.8 mg/kg (i.v.). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Conscious, coronary artery ligated dogsDosage: Oral administration (p.o.) Administration: 2.5 and 5 mg/kg Result: Restored normal sinus rhythm, and showed a long duration of activity, wide safety margin.

Form:Solid

IC50& Target:IC50: 0.1 μM (I K.ACh )

Specifications

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

Pirmenol ((±)-Pirmenol) hydrochloride is an orally active antiarrhythmic agent. Pirmenol hydrochloride inhibits I K.ACh ( IC 50 : 0.1 μM) by blocking mAchR . Pirmenol hydrochloride can be used in the research of cardiovascular disease , such as atrial fib

Storage

Store at 2-8°C

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥99%

Names and Identifiers

• Isomeric SMILES: C[C@@H]1CCC[C@@H](N1CCCC(C2=CC=CC=C2)(C3=CC=CC=N3)O)C.Cl
• PubChem CID: 65501
• Molecular Weight: 374.95

Chemical and Physical Properties

• Solubility: DMSO : 125 mg/mL (333.38 mM; Need ultrasonic) H2O : 100 mg/mL (266.70 mM; Need ultrasonic)
• Molecular Weight: 374.900 g/mol
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 374.212 Da
• Monoisotopic Mass: 374.212 Da
• Topological Polar Surface Area: 36.400 Ų
• Heavy Atom Count: 26
• Formal Charge: 0
• Complexity: 385.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 2
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

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