Promethazine hydrochlorine - ≥98%(HPLC) , CAS No.58-33-3

CAS: 58-33-3 Cat. No.: P133927 Molecular Weight: 320.88 Beilstein Registry Number: 4166397 EC Number: 200-375-2 PubChem CID: 6014

6 Citations COA

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Promethazine hydrochlorine - ≥98%(HPLC) CAS No(58-33-3) by Aladdin Scientific

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AVAILABLE TO ORDER

GRADE & PURITY ≥98%(HPLC)

Synonyms

PROMETHAZINE HYDROCHLORIDE COMPONENT OF PHERAZINE DM | 58-33-3 (HCl) | N,N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine hydrochloride | 10-(2-(DIMETHYLAMINO)PROPYL)PHENOTHIAZINE HYDROCHLORIDE | N,N-dimethyl-1-phenothiazin-10-ylpropan-2-amine;hydrochl

Storage

Protected from light,Room temperature

Shipped In

Normal

Overview Specifications Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Citations of This Product References Solution Calculators Reviews

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Why this grade

≥98%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Protected from light,Room temperature Ships Normal Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 6 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Promethazine Hydrochloride is an antiemetic, antihistaminic, and CNS depressant.
An antagonist of the histamine H1-receptor.

Specifications

Synonyms

PROMETHAZINE HYDROCHLORIDE COMPONENT OF PHERAZINE DM | 58-33-3 (HCl) | N, N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine hydrochloride | 10-(2-(DIMETHYLAMINO)PROPYL)PHENOTHIAZINE HYDROCHLORIDE | N, N-dimethyl-1-phenothiazin-10-ylpropan-2-amine;hydrochl

Specifications & Purity

≥98%(HPLC)

Biochemical and Physiological Mechanisms

H 1 组胺受体拮抗剂；CNS 抑制剂

Storage

Protected from light, Room temperature

Shipped In

Normal

Purity

≥98%(HPLC)

Names and Identifiers

Pubchem Sid	504750983
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504750983
Canonical Smiles	CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)C.Cl
IUPAC Name	N,N-dimethyl-1-phenothiazin-10-ylpropan-2-amine;hydrochloride
InChIKey	XXPDBLUZJRXNNZ-UHFFFAOYSA-N
INCHI	1S/C17H20N2S.ClH/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19;/h4-11,13H,12H2,1-3H3;1H
Isomeric SMILES	CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)C.Cl
WGK Germany	3
RTECS	SO8225000
Alternate CAS	60-87-7
PubChem CID	6014
Molecular Weight	320.88
Beilstein	4166397
Reaxy-Rn	4166397

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Benzothiazines
    - Subclass Phenothiazines

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Benzothiazines
Subclass	Phenothiazines
Intermediate Tree Nodes	Not available
Direct Parent	Phenothiazines
Alternative Parents	Alkyldiarylamines Diarylthioethers Benzenoids 1,4-thiazines Trialkylamines Azacyclic compounds Organopnictogen compounds Hydrochlorides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Phenothiazine - Alkyldiarylamine - Diarylthioether - Aryl thioether - Tertiary aliphatic/aromatic amine - Para-thiazine - Benzenoid - Tertiary aliphatic amine - Tertiary amine - Thioether - Azacycle - Hydrocarbon derivative - Amine - Organopnictogen compound - Organic nitrogen compound - Organonitrogen compound - Hydrochloride - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as phenothiazines. These are polycyclic aromatic compounds containing a phenothiazine moiety, which is a linear tricyclic system that consists of a two benzene rings joined by a para-thiazine ring.
External Descriptors	hydrochloride
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(Human)

PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)

Discover Target: PPARG

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KCNH2 Tclin HERG (29587 Activities)

Discover Target: KCNH2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TRPV1 Tclin Vanilloid receptor (8273 Activities)

Discover Target: TRPV1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALOX15B Tchem Arachidonate 15-lipoxygenase, type II (7244 Activities)

Discover Target: ALOX15B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NFKB1 Tclin Nuclear factor NF-kappa-B p105 subunit (1459 Activities)

Discover Target: NFKB1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A498 (42825 Activities)

Lot Number	Certificate Type	Date	Item
H2420127	Certificate of Analysis	Jun 09, 2026	P133927
J2222431	Certificate of Analysis	May 11, 2026	P133927
J2222432	Certificate of Analysis	May 11, 2026	P133927
J2222475	Certificate of Analysis	May 11, 2026	P133927
B2628122	Certificate of Analysis	Mar 11, 2026	P133927
K2317035	Certificate of Analysis	Sep 04, 2025	P133927
K2104537	Certificate of Analysis	Aug 07, 2023	P133927
K2104538	Certificate of Analysis	Aug 07, 2023	P133927
J1527046	Certificate of Analysis	May 10, 2023	P133927

Solubility	Soluble in ethanol; insoluble in ether
Sensitivity	Light sensitive；Moisture sensitive；Air sensitive
Melt Point(°C)	226 °C
Molecular Weight	320.900 g/mol
XLogP3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Exact Mass	320.111 Da
Monoisotopic Mass	320.111 Da
Topological Polar Surface Area	31.800 Å²
Heavy Atom Count	21
Formal Charge	0
Complexity	298.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

Promethazine hydrochlorine - ≥98%(HPLC) , CAS No.58-33-3

Why this grade

Storage & shipping

Quality documents

Literature proof

Overview

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Customer Reviews

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