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PXS-5120A - ≥98% , CAS No.2125955-70-4
AVAILABLE TO ORDER
GRADE & PURITY ≥98%
Storage
Store at 2-8°C,Desiccated
Shipped In
Wet ice
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Why this grade
≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at 2-8°C,Desiccated Ships Wet ice Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
PXS-5120A is a potent, irreversible fluoroallylamine inhibitor of Lysyl Oxidase-like 2/3 (LOXL2/3) with anti-fibrotic activity. PXS-5120A is >300-fold selective for LOXL2 ( K i of 83 nM; pIC 50 of 8.4) over LOXL ( pIC 50 of 5.8)
In Vitro
PXS-5120A (Compound 12k) is a potent inhibitor of the LOXL2/3 enzyme and a moderate blocker of LOXL4. PXS-5120A inhibits recombinant human LOXL2, human fibroblast LOXL2, recombinant mouse LOXL2, recombinant rat LOXL2, collagen oxidation assay, recombinant human LOXL3 and recombinant human LOXL4 with IC 50 s of 5 nM, 9 nM, 6 nM, 6 nM, 13 nM, 16 nM and 280 nM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
PXS-5129A is readily absorbed following oral gavage, and once in the circulation, rapidly hydrolyzed to release PXS-5120 (free base) in vivo, affording plasma concentrations well above the LOXL2 IC 50 (6 nM) for a prolonged period (>6 h) in mice, while remaining well below the IC50 for LOX throughout . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:pKi: 8.4 (Lysyl Oxidase-like 2) and 5.8 (Lysyl Oxidase-like),Ki: 83 nM (Lysyl Oxidase-like 2)
Specifications
Specifications & Purity
≥98%
Biochemical and Physiological Mechanisms
PXS-5120A is a potent, irreversible fluoroallylamine inhibitor of Lysyl Oxidase-like 2/3 (LOXL2/3) with anti-fibrotic activity. PXS-5120A is >300-fold selective for LOXL2 ( K i of 83 nM; pIC 50 of 8.4) over LOXL ( pIC 50 of 5.8).
Storage
Store at 2-8°C, Desiccated
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Purity
≥98%
Names and Identifiers
| Canonical Smiles | O=C(C1=CC2=C(N(C/C(F)=C/CN)C(C)=C2C3=CC=CC(S(=O)(N(C)C)=O)=C3)C=C1)O.[H]Cl |
|---|---|
| Molecular Weight | 481.97 |
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
| Solubility | DMSO : 125 mg/mL (259.35 mM; Need ultrasonic) |
|---|
Solution Calculators
Reviews
Customer Reviews
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