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RG7800 hydrochloride - ≥99% , CAS No.R659305
AVAILABLE TO ORDER
GRADE & PURITY ≥99%
Storage
Store at 2-8°C,Desiccated
Shipped In
Wet ice
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Why this grade
≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at 2-8°C,Desiccated Ships Wet ice Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
RG7800 hydrochloride is an orally active SMN2 splicing modulator, with EC 1.5x s of 23 nM and 87 nM for SMN2 splicing and SMN protein ; RG7800 hydrochloride has the potential to treat spinal muscular atrophy.
Appearance:Solid
IC50& Target:EC1.5x: 23 nM ( SMN2 splicing), 87 nM (SMN protein)
In Vitro:RG7800 hydrochloride is an orally active SMN2 splicing modulator, with EC 1.5x s of 23 nM and 87 nM for SMN2 splicing and SMN protein; and is the first small molecule SMN2 splicing modifier to enter human clinical trials. MCE has not independently co
In Vivo:RG7800 is a favorable agent metabolism and pharmacokinetic (DMPK) profile in the rat and in cynomolgus monkey with good oral bioavailability. RG7800 (1, 3, 10mg/kg, p.o.) dose-dependently elevates the SMN protein level in the brain and in peripheral tiss
Biological Activity:RG7800 hydrochloride is an orally active SMN2 splicing modulator, with EC 1.5x s of 23 nM and 87 nM for SMN2 splicing and SMN protein ; RG7800 hydrochloride has the potential to treat spinal muscular atrophy.
Specifications
Specifications & Purity
≥99%
Storage
Store at 2-8°C, Desiccated
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Purity
≥99%
Names and Identifiers
| Canonical Smiles | CC1=CC(C2CCN(C)CC2)=CN3C1=NC(C4=NN(C=C(C)N=C5CC)C5=C4)=CC3=O.[xHCl] |
|---|
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificates（CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
| Solubility | H2O : ≥ 113.5 mg/mL |
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Solution Calculators
Reviews
Customer Reviews
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