Ropivacaine HCl - 10mM in DMSO , Sodium channel alpha subunit blocker, CAS No.98717-15-8, Sodium channel alpha subunit blocker

CAS: 98717-15-8 Cat. No.: R408524 Molecular Weight: 310.86 EC Number: 691-259-4 PubChem CID: 175804

GRADE & PURITY 10mM in DMSO

Synonyms

LEA-103 HCl | 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-propyl-, hydrochloride (1:1), (2S)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Ropivacaine HCl Ropivacaine HCl (LEA-103) is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly.
In vitro

Ropivacaine HCl is a local anaesthetic agent. Ropivacaine HCl elicits nerve block via reversible inhibition of sodium ion influx in nerve fibres. The pKa of ropivacaine HCl is ~8.2. Ropivacaine HCl has the potential to induce cardiovascular toxicity and CNS toxicity at high plasma concentrations.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

LEA-103 HCl | 2-Piperidinecarboxamide, N-(2, 6-dimethylphenyl)-1-propyl-, hydrochloride (1:1), (2S)-

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Ropivacaine HCl (LEA-103) is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

BLOCKER

Mechanism of action

Sodium channel alpha subunit blocker

Names and Identifiers

• Isomeric SMILES: CCCN1CCCC[C@H]1C(=O)NC2=C(C=CC=C2C)C.Cl
• PubChem CID: 175804
• Molecular Weight: 310.86

References

1. Xiaokang Guan, Qiao Lu, Xiangxu Zhao, Xiaowen Yan, Renato Zenobi.  (2023)  Spatio-Temporal Analysis of Anesthetics in Mice by Solid-Phase Microextraction: Dielectric Barrier Discharge Ionization Mass Spectrometry.  ANALYTICAL CHEMISTRY,      [PMID:37560898] [10.1021/acs.analchem.3c02123]

2. Ce Wu, Di Wu, LiJie Xie, HouYong Yan, Wei Zhang, Fei Yu.  (2026)  Near-Infrared Responsive Injectable Thermosensitive Hydrogel Sequentially Releases Dexmedetomidine and Ropivacaine for Postoperative Pain Management.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,      [PMID:] [10.1016/j.colsurfa.2026.139503]