(S)-(-)-5-Fluorowillardiine - Moligand™, ≥98% , Agonist of GluA1;Agonist of GluA2;Agonist of GluA3;Agonist of GluA4, CAS No.140187-23-1, Agonist of GluA1;Agonist of GluA2;Agonist of GluA3;Agonist of GluA4

CAS: 140187-23-1 Cat. No.: F347382 Molecular Weight: 217.15 EC Number: 634-285-3

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(S)-(-)-5-Fluorowillardiine - Moligand™, ≥98% CAS No(140187-23-1) by Aladdin Scientific

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AVAILABLE TO ORDER

GRADE & PURITY Moligand™ ? ≥98%

Synonyms

(5S)-Fluorowillardiine | 5-Fluorowillardiine | J-007366 | KBio2_001794 | SR-01000597628-1 | EX-A4515 | F-205 | FWD | UNII-7CTR2LWV5M | (S)-F-Willardiine | 3-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine | BRN 2299701 | (S)-5-FLUOROWILLARDII

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview Specifications Product Properties Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solution Calculators Reviews

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Why this grade

Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

(S)-(-)-5-Fluorowillardiine is an extremely potent and selective AMPA receptor agonist at hGluR1 and hGluR2. AMPA is a transmembrane glutamate receptor composed of the subunits GluR-1,2,3,4.

Specifications

Synonyms

(5S)-Fluorowillardiine | 5-Fluorowillardiine | J-007366 | KBio2_001794 | SR-01000597628-1 | EX-A4515 | F-205 | FWD | UNII-7CTR2LWV5M | (S)-F-Willardiine | 3-(5-fluoro-2, 4-dioxo-3, 4-dihydropyrimidin-1(2H)-yl)-L-alanine | BRN 2299701 | (S)-5-FLUOROWILLARDII

Specifications & Purity

Moligand™, ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

AGONIST

Mechanism of action

Agonist of GluA1;Agonist of GluA2;Agonist of GluA3;Agonist of GluA4

Purity

≥98%

Product Properties

pKa	pKₐ: 2.12 (Predicted), pKₐ: 9.6 (Predicted)
Ki Data	Glutamate receptor ionotropic, AMPA 1: Ki= 2.9 nM (rat); Glutamate receptor ionotropic, AMPA 2: Ki= 4 nM (rat); hGluR1: Ki= 14.7 nM; hGluR2 : Ki= 25.1 nM; hGluR5: Ki= 1.82 μM

Names and Identifiers

Canonical Smiles	C1=C(C(=O)NC(=O)N1CC(C(=O)O)N)F
IUPAC Name	(2S)-2-amino-3-(5-fluoro-2,4-dioxopyrimidin-1-yl)propanoic acid
InChIKey	DBWPFHJYSTVBCZ-BYPYZUCNSA-N
INCHI	1S/C7H8FN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)/t4-/m0/s1
Isomeric SMILES	C1=C(C(=O)NC(=O)N1C[C@@H](C(=O)O)N)F
Molecular Weight	217.15
Reaxy-Rn	1584814
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1584814&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic acids and derivatives
  - Class Carboxylic acids and derivatives
    - Subclass Amino acids, peptides, and analogues
      - Level5 Amino acids and derivatives
        Level6 Alpha amino acids and derivatives
        Level7 Alpha amino acids
        Level8 L-alpha-amino acids

Kingdom	Organic compounds
Superclass	Organic acids and derivatives
Class	Carboxylic acids and derivatives
Subclass	Amino acids, peptides, and analogues
Intermediate Tree Nodes	Amino acids and derivatives - Alpha amino acids and derivatives - Alpha amino acids
Direct Parent	L-alpha-amino acids
Alternative Parents	Pyrimidones Halopyrimidines Hydroxypyrimidines Aryl fluorides Hydropyrimidines Heteroaromatic compounds Amino acids Azacyclic compounds Carboxylic acids Monocarboxylic acids and derivatives Organic oxides Organofluorides Carbonyl compounds Organopnictogen compounds Hydrocarbon derivatives Monoalkylamines
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	L-alpha-amino acid - Halopyrimidine - Hydroxypyrimidine - Pyrimidone - Aryl fluoride - Aryl halide - Hydropyrimidine - Pyrimidine - Heteroaromatic compound - Amino acid - Carboxylic acid - Azacycle - Organoheterocyclic compound - Monocarboxylic acid or derivatives - Amine - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Primary amine - Primary aliphatic amine - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Carbonyl group - Organic oxygen compound - Organic nitrogen compound - Aromatic heteromonocyclic compound
Description	This compound belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom.
External Descriptors	organofluorine compound - non-proteinogenic L-alpha-amino acid - L-alanine derivative
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(Human)

GRIA4 Tclin Glutamate receptor 4 (1 Activities)

Discover Target: GRIA4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIK5 Tclin Glutamate receptor ionotropic, kainate 5 (1 Activities)

Discover Target: GRIK5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIA2 Tclin Glutamate receptor 2 (2 Activities)

Discover Target: GRIA2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIA3 Tclin Glutamate receptor 3 (0 Activities)

Discover Target: GRIA3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIA1 Tclin Glutamate receptor 1 (3 Activities)

Discover Target: GRIA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIA3 Tclin Glutamate receptor ionotropic, AMPA 3 (127 Activities)

Discover Target: GRIA3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GRIA1 Tclin Glutamate receptor ionotropic, AMPA 1 (277 Activities)

Discover Target: GRIA1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GRIA2 Tclin Glutamate receptor ionotropic, AMPA 2 (847 Activities)

Discover Target: GRIA2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

Discover Target: CYP2D6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GRIK5 Tclin Glutamate receptor ionotropic kainate 5 (45 Activities)

Discover Target: GRIK5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GRIK1 Tclin Glutamate receptor ionotropic kainate 1 (340 Activities)

Discover Target: GRIK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)

Discover Target: CYP1A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)

Discover Target: CYP2C9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)

Discover Target: CYP2C19

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

Discover Target: CYP3A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

U2OS (164939 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)

Discover Target: KDM4E

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Gria4 Glutamate receptor ionotropic, AMPA 4 (112 Activities)

Discover Target: Gria4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Grik2 Glutamate receptor ionotropic kainate 2 (298 Activities)

Discover Target: Grik2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)

Discover Target: ffp

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number	Certificate Type	Date	Item
I2222980	Certificate of Analysis	Jul 10, 2025	F347382
I2222981	Certificate of Analysis	Jul 10, 2025	F347382
I2222982	Certificate of Analysis	Jul 10, 2025	F347382
I2222983	Certificate of Analysis	Jul 10, 2025	F347382
I2222984	Certificate of Analysis	Jul 10, 2025	F347382

Chemical and Physical Properties

Solubility	Soluble in 1.1eq. NaOH (50 mM), and water (partly).
Refractive Index	n20D1.60 (Predicted)
Specific Rotation[α]	α20/D -22°, c = 1 in 6N HCl
Boil Point(°C)	529.21° C (Predicted)
Melt Point(°C)	311.22° C (Predicted)
Molecular Weight	217.150 g/mol
XLogP3	-4.400
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	3
Exact Mass	217.05 Da
Monoisotopic Mass	217.05 Da
Topological Polar Surface Area	113.000 Å²
Heavy Atom Count	15
Formal Charge	0
Complexity	354.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

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