Syrosingopine (Su 3118) is an orally active lactate transporters (MCT1/MCT4) dual inhibitor, which can reduce glycolysis and induce synthetic lethality in cancer cells when combine with metformin. Syrosingopine shows anti-hypertensive activity by depleting peripheral stores of norepinephrine.

Specifications

Synonyms

Londomin | Prestwick_457 | Syrosingopine (JAN/INN) | Yohimban-16-carboxylic acid, 5-dimethoxybenzoyl]oxy]-11, 17-dimethoxy-, methyl ester, (3.beta., 16.beta., 17.alpha., 18.beta., 20.alpha.)- | DTXSID9023629 | Syringic acid ethyl carbonate ester with methyl res

Specifications & Purity

≥98%

Storage

Protected from light, Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥98%

Names and Identifiers

Pubchem Sid	504751166
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504751166
Canonical Smiles	CCOC(=O)OC1=C(C=C(C=C1OC)C(=O)OC2CC3CN4CCC5=C(C4CC3C(C2OC)C(=O)OC)NC6=C5C=CC(=C6)OC)OC
IUPAC Name	methyl (1R,15S,17R,18R,19S,20S)-17-(4-ethoxycarbonyloxy-3,5-dimethoxybenzoyl)oxy-6,18-dimethoxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate
InChIKey	ZCDNRPPFBQDQHR-SSYATKPKSA-N
INCHI	1S/C35H42N2O11/c1-7-46-35(40)48-31-26(42-3)12-18(13-27(31)43-4)33(38)47-28-14-19-17-37-11-10-22-21-9-8-20(41-2)15-24(21)36-30(22)25(37)16-23(19)29(32(28)44-5)34(39)45-6/h8-9,12-13,15,19,23,25,28-29,32,36H,7,10-11,14,16-17H2,1-6H3/t19-,23+,25-,28-,29+,32+/m1/s1
Isomeric SMILES	CCOC(=O)OC1=C(C=C(C=C1OC)C(=O)O[C@@H]2C[C@@H]3CN4CCC5=C([C@H]4C[C@@H]3[C@@H]([C@H]2OC)C(=O)OC)NC6=C5C=CC(=C6)OC)OC
PubChem CID	6769
Molecular Weight	666.71

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

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✅ Certificate of Analysis (COA)

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📊 Datasheet

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🔬 Specification Sheet

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Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Alkaloids and derivatives
  - Class Yohimbine alkaloids

Kingdom	Organic compounds
Superclass	Alkaloids and derivatives
Class	Yohimbine alkaloids
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Yohimbine alkaloids
Alternative Parents	Corynanthean-type alkaloids Beta carbolines Gallic acid and derivatives M-methoxybenzoic acids and derivatives 3-alkylindoles Benzoic acid esters Dimethoxybenzenes Anisoles Phenoxy compounds Benzoyl derivatives Alkyl aryl ethers Aralkylamines Piperidines Carbonic acid diesters Dicarboxylic acids and derivatives Pyrroles Methyl esters Heteroaromatic compounds Trialkylamines Amino acids and derivatives Azacyclic compounds Dialkyl ethers Carbonyl compounds Hydrocarbon derivatives Organic oxides Organopnictogen compounds
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Yohimbine - Corynanthean skeleton - Yohimbine alkaloid - Beta-carboline - Pyridoindole - Gallic acid or derivatives - M-methoxybenzoic acid or derivatives - Benzoate ester - M-dimethoxybenzene - Dimethoxybenzene - 3-alkylindole - Indole - Indole or derivatives - Benzoic acid or derivatives - Phenoxy compound - Anisole - Phenol ether - Methoxybenzene - Benzoyl - Alkyl aryl ether - Aralkylamine - Piperidine - Carbonic acid diester - Monocyclic benzene moiety - Dicarboxylic acid or derivatives - Benzenoid - Pyrrole - Heteroaromatic compound - Methyl ester - Tertiary amine - Carboxylic acid ester - Carbonic acid derivative - Tertiary aliphatic amine - Amino acid or derivatives - Azacycle - Organoheterocyclic compound - Carboxylic acid derivative - Ether - Dialkyl ether - Organooxygen compound - Amine - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Organonitrogen compound - Carbonyl group - Organic oxygen compound - Organopnictogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as yohimbine alkaloids. These are alkaloids containing the pentacyclic yohimban skeleton. The Yohimbinoid alkaloids contain a carbocyclic ring E arising through C-17 to C-18 bond formation in a corynantheine precursor.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(Human)

ACHE Tclin Acetylcholinesterase (18204 Activities)

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CXCL8 Tchem Interleukin-8 (642 Activities)

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GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)

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PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (36611 Activities)

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HEK293 (82097 Activities)

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HepG2 (196354 Activities)

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P4HB Tchem Protein disulfide-isomerase (716 Activities)

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KDM4A Tchem Lysine-specific demethylase 4A (52245 Activities)

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EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

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SMAD3 Tchem Mothers against decapentaplegic homolog 3 (68039 Activities)

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GMNN Tbio Geminin (128009 Activities)

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ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)

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BAZ2B Tchem Bromodomain adjacent to zinc finger domain protein 2B (56204 Activities)

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IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (40980 Activities)

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APOBEC3F Tbio DNA dC->dU-editing enzyme APOBEC-3F (14861 Activities)

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SLC16A3 Tchem Monocarboxylate transporter 4 (196 Activities)

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RAN Tchem GTP-binding nuclear protein Ran/Importin subunit beta-1/Snurportin-1 (21853 Activities)

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Associated Targets(non-human)

Plasmodium falciparum (966862 Activities)

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Vero (26788 Activities)

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BCHE Cholinesterase (8742 Activities)

Discover Target: BCHE

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Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

Discover Target: Nfe2l2

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Mechanisms of Action

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot Number	Certificate Type	Date	Item
C23031117	Certificate of Analysis	Jan 05, 2026	S420060
C23031112	Certificate of Analysis	Jan 05, 2026	S420060
C23031072	Certificate of Analysis	Jan 05, 2026	S420060
C23031062	Certificate of Analysis	Jan 05, 2026	S420060
C23031061	Certificate of Analysis	Jan 05, 2026	S420060
C2520553	Certificate of Analysis	Oct 11, 2022	S420060

Chemical and Physical Properties

Sensitivity	Light sensitive
Molecular Weight	666.700 g/mol
XLogP3	4.600
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	13
Exact Mass	666.279 Da
Monoisotopic Mass	666.279 Da
Topological Polar Surface Area	144.000 Å²
Heavy Atom Count	48
Formal Charge	0
Complexity	1130.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	6
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Solution Calculators

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Syrosingopine (Su-3118) - ≥98% , CAS No.84-36-6

Why this grade

Storage & shipping

Quality documents

Literature proof

Overview

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Customer Reviews

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