Tetramethyl Nordihydroguaiaretic Acid is a synthetic derivative of NDGA and a non-selective LO (lipoxygenase) inhibitor. Tetramethyl Nordihydroguaiaretic Acid inhibits Sp1 transcription factor binding at the HIV long terminal repeat promoter and at the α-ICP4 promoter (a gene essential for HSV replication).

Specifications

Synonyms

Specifications & Purity

Moligand™, ≥95%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

DNA inhibitor

Purity

≥95%

Product Properties

ALogP	5.6

Names and Identifiers

Canonical Smiles	CC(CC1=CC(=C(C=C1)OC)OC)C(C)CC2=CC(=C(C=C2)OC)OC
IUPAC Name	4-[(2S,3R)-4-(3,4-dimethoxyphenyl)-2,3-dimethylbutyl]-1,2-dimethoxybenzene
InChIKey	ORQFDHFZSMXRLM-IYBDPMFKSA-N
INCHI	1S/C22H30O4/c1-15(11-17-7-9-19(23-3)21(13-17)25-5)16(2)12-18-8-10-20(24-4)22(14-18)26-6/h7-10,13-16H,11-12H2,1-6H3/t15-,16+
Isomeric SMILES	C[C@H](CC1=CC(=C(C=C1)OC)OC)[C@@H](C)CC2=CC(=C(C=C2)OC)OC
WGK Germany	3
PubChem CID	476861
UN Number	3077
Packing Group	III
Molecular Weight	358.47

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

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✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

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📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

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Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Lignans, neolignans and related compounds
  - Class Dibenzylbutane lignans

Kingdom	Organic compounds
Superclass	Lignans, neolignans and related compounds
Class	Dibenzylbutane lignans
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Dibenzylbutane lignans
Alternative Parents	Dimethoxybenzenes Phenylpropanes Phenoxy compounds Anisoles Alkyl aryl ethers Hydrocarbon derivatives
Molecular Framework	Aromatic homomonocyclic compounds
Substituents	Dibenzylbutane lignan skeleton - Dimethoxybenzene - O-dimethoxybenzene - Phenylpropane - Phenol ether - Phenoxy compound - Anisole - Methoxybenzene - Alkyl aryl ether - Benzenoid - Monocyclic benzene moiety - Ether - Hydrocarbon derivative - Organic oxygen compound - Organooxygen compound - Aromatic homomonocyclic compound
Description	This compound belongs to the class of organic compounds known as dibenzylbutane lignans. These are lignan compounds containing a 2,3-dibenzylbutane moiety.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(Human)

ALOX12 Tchem Arachidonate 12-lipoxygenase (3262 Activities)

Discover Target: ALOX12

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALOX15 Tchem Arachidonate 15-lipoxygenase (7108 Activities)

Discover Target: ALOX15

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A-375 (9258 Activities)

Lot Number	Certificate Type	Date	Item
D2610590	Certificate of Analysis	Jan 08, 2026	T339697
D2610593	Certificate of Analysis	Jan 08, 2026	T339697
D2610594	Certificate of Analysis	Jan 08, 2026	T339697

Solubility	Soluble in 1:3 DMF: PBS(pH 7.2) (~0.25 mg/ml), ethanol (~0.2 mg/ml), DMSO (~2 mg/ml), and DMF (~2 mg/ml).
Refractive Index	n20D1.52 (Predicted)
Boil Point(°C)	~458.5° C at 760 mmHg (Predicted)
Melt Point(°C)	155.67° C (Predicted)
Molecular Weight	358.500 g/mol
XLogP3	5.600
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	9
Exact Mass	358.214 Da
Monoisotopic Mass	358.214 Da
Topological Polar Surface Area	36.900 Å²
Heavy Atom Count	26
Formal Charge	0
Complexity	352.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Terameprocol - Moligand™,≥95% , DNA inhibitor, CAS No.24150-24-1, DNA inhibitor

Why this grade

Storage & shipping

Quality documents

Literature proof

Overview

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

Molarity Calculator

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Reconstitution Calculator

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