Tetramethylurea - ≥99% , CAS No.632-22-4

CAS: 632-22-4 Cat. No.: T110882 Molecular Weight: 116.16 Beilstein Registry Number: 773898 EC Number: 211-173-9

GRADE & PURITY ≥99%

Synonyms

Urea, tetramethyl- | Q26699773 | 4-04-00-00225 (Beilstein Handbook Reference) | Urea, 1,1,3,3-tetramethyl- | Tetramethylurea, 99% | UREA,1,1,3,3-TETRAMETHYL | BRN 0773898 | D70479 | n,n,n',n',-tetramethyl urea | urea, N,N,N',N'-tetramethyl- | N,N,N',N'-te

Storage

Room temperature

Shipped In

Normal

Specifications

Synonyms

Urea, tetramethyl- | Q26699773 | 4-04-00-00225 (Beilstein Handbook Reference) | Urea, 1, 1, 3, 3-tetramethyl- | Tetramethylurea, 99% | UREA, 1, 1, 3, 3-TETRAMETHYL | BRN 0773898 | D70479 | n, n, n', n', -tetramethyl urea | urea, N, N, N', N'-tetramethyl- | N, N, N', N'-te

Specifications & Purity

≥99%

Storage

Room temperature

Shipped In

Normal

Purity

≥99%

Names and Identifiers

• Pubchem Sid: 504752340
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504752340
• Canonical Smiles: CN(C)C(=O)N(C)C
• IUPAC Name: 1,1,3,3-tetramethylurea
• InChIKey: AVQQQNCBBIEMEU-UHFFFAOYSA-N
• INCHI: 1S/C5H12N2O/c1-6(2)5(8)7(3)4/h1-4H3
• Isomeric SMILES: CN(C)C(=O)N(C)C
• WGK Germany: 3
• RTECS: YU2625000
• Molecular Weight: 116.16
• Beilstein: 773898
• Reaxy-Rn: 773898

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Organic carbonic acids and derivatives
      • Subclass Ureas

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Organic carbonic acids and derivatives
• Subclass: Ureas
• Intermediate Tree Nodes: Not available
• Direct Parent: Ureas
• Alternative Parents: Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Urea - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Carbonyl group - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as ureas. These are compounds containing two amine groups joined by a carbonyl (C=O) functional group.
• External Descriptors: ureas

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Solubility in water: Completely miscible; Miscible with Alcohol,Ether
• Sensitivity: Hygroscopic
• Refractive Index: 1.4496-1.4516
• Flash Point(°F): 167 °F
• Flash Point(°C): 75℃
• Boil Point(°C): 174-178°C
• Melt Point(°C): -1°C
• Molecular Weight: 116.160 g/mol
• XLogP3: 0.200
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 116.095 Da
• Monoisotopic Mass: 116.095 Da
• Topological Polar Surface Area: 23.600 Ų
• Heavy Atom Count: 8
• Formal Charge: 0
• Complexity: 78.400
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Yu Cao, Shangtao Chen, Dongshun Deng.  (2023)  Insight of interaction in kojic acid/urea derivatives deep eutectic solvent from physicochemical characterization and computation simulation.  JOURNAL OF MOLECULAR LIQUIDS,      [PMID:] [10.1016/j.molliq.2023.123547]

2. Ying Zhang, Jian Ye, Yinzhi Jiang, Shuqin Jiang, Wei Xiao, Dongchu Wei.  (2023)  Alkylaluminum/Urea Hybrid Cocatalysts and Their Use in Iron-Catalyzed Oligomerization of Ethylene.  Macromolecular Reaction Engineering,  17  (3): (2300013).  [PMID:] [10.1002/mren.202300013]

3. Qiang Wan, Huiyong Wang, Shuangyu Li, Jianji Wang.  (2018)  Efficient liquid-phase exfoliation of few-layer graphene in aqueous 1, 1, 3, 3-tetramethylurea solution.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,      [PMID:29729968] [10.1016/j.jcis.2018.04.110]

4. Mengjie Wu, Wei Zhou, Christian Marcus Pedersen, Hui Ma, Yan Qiao, Xiaoya Guo, Xianglin Hou, Yingxiong Wang.  (2018)  Isomeric distribution of monosaccharides in deep eutectic solvents: NMR study.  JOURNAL OF MOLECULAR LIQUIDS,      [PMID:] [10.1016/j.molliq.2018.01.166]

5. Xiaoliang Li, Jie Cheng, Yanxiang Liu, Shoutao Gong, Gaohong He, Lingdong Li, Shanshan Li, Fengxiang Zhang.  (2017)  Improved conductivity and stability of anion exchange membrane modified with bi-phenylguanidinium bridged silsesquioxane.  INTERNATIONAL JOURNAL OF HYDROGEN ENERGY,      [PMID:] [10.1016/j.ijhydene.2017.07.081]

6. Yaotai Jiang, Xiaobang Liu, Dongshun Deng.  (2016)  Solubility and thermodynamic properties of SO2 in three low volatile urea derivatives.  JOURNAL OF CHEMICAL THERMODYNAMICS,      [PMID:] [10.1016/j.jct.2016.05.004]

7. Xiaofeng Li, Yaotai Jiang, Guoqiang Han, Dongshun Deng.  (2016)  Investigation of the Solubilities of Carbon Dioxide in Some Low Volatile Solvents and Their Thermodynamic Properties.  JOURNAL OF CHEMICAL AND ENGINEERING DATA,      [PMID:] [10.1021/acs.jced.5b00893]

8. Yuan Debao, Xu Yinghao, Wang Chaozheng, Li Yixing, Li Fenfang, Zhou Ya, Chen Jiao, Jin Zhiqiang, Zhang Haide, Jiang Yueming.  (2015)  Comparison of anti-browning ability and characteristics of the fractionated Maillard reaction products with different polarities.  JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE,  52  (11): (7163-7172).  [PMID:] [10.1007/s13197-015-1869-1]

9. Jiechen Song, Yuxing Xu, Yuncheng Zhou, Rui He, Ai-Jia Wei, Qiangqiang Tan.  (2024)  Enabling scalable composite solid electrolyte by cathode-supported scale-up processing.  Journal of Materials Chemistry A,      [PMID:] [10.1039/D4TA05313C]

10. Huiyong Wang, Shuangyu Li, Qiang Wan, Xin Su, Tao Song, Xiaobing Wang, Jianji Wang.  (2020)  Highly efficient solution exfoliation of few-layer molybdenum disulfide nanosheets for photocatalytic hydrogen evolution.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,      [PMID:32464337] [10.1016/j.jcis.2020.05.034]

11. Yan Zhang, Xiaowei Chen, Wei Li, Baoyi Wang, Qian Zhang, Zhuo Zhao, Yafei Wang, Ying Guan, Yongjun Zhang.  (2025)  Construction of Stretchable, Tough and Damped Eutectogel Resistant to −100 °C using 2-Methyl-1,3-Propanediol Based Deep Eutectic Solvent.  ADVANCED FUNCTIONAL MATERIALS,      [PMID:] [10.1002/adfm.202511554]

12. Sibo Wang, Chen Li, Wanlong Wu, Guoli Zhang, Razium Ali Soomro, Wenchao Fu, Xiaoqi Sun, Bin Xu.  (2025)  Interface Chemistry and Reaction Pathway Regulation for Boosted Redox Kinetics in Aqueous Zn–S Batteries.  Advanced Science,      [PMID:41194400] [10.1002/advs.202513155]