Tezacaftor (VX-661) - Moligand™, 10mM in DMSO , Cystic fibrosis transmembrane conductance regulator positive modulator, CAS No.1152311-62-0, Cystic fibrosis transmembrane conductance regulator positive modulator

CAS: 1152311-62-0 Cat. No.: T407910 Molecular Weight: 520.5 EC Number: 810-780-1 PubChem CID: 46199646

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Cyclopropanecarboxamide, 1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-[1-[(2R)-2,3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1,1-dimethylethyl)-1H-indol-5-yl]-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Tezacaftor (VX-661) Tezacaftor (VX-661) is a second F508del CFTR corrector and is believed to help CFTR protein reach the cell surface. Phase 2.
In vitro

VX-661, known as a CTFR corrector, allows F508del mutant channels to escape degradation and transit to the cell membrane.

In vivo

Cell Data

cell lines：TERT/LT/ST/RASV12\xa0cells\xa0

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

Cyclopropanecarboxamide, 1-(2, 2-difluoro-1, 3-benzodioxol-5-yl)-N-[1-[(2R)-2, 3-dihydroxypropyl]-6-fluoro-2-(2-hydroxy-1, 1-dimethylethyl)-1H-indol-5-yl]-

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Tezacaftor\xa0(VX-661) is a second F508del CFTR corrector and is believed to help CFTR protein reach the cell surface. Phase 2.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

POSITIVE MODULATOR

Mechanism of action

Cystic fibrosis transmembrane conductance regulator positive modulator

Product Properties

• ALogP: 2.9

Names and Identifiers

• Isomeric SMILES: CC(C)(CO)C1=CC2=CC(=C(C=C2N1C[C@H](CO)O)F)NC(=O)C3(CC3)C4=CC5=C(C=C4)OC(O5)(F)F
• PubChem CID: 46199646
• Molecular Weight: 520.5

Associated Targets(Human)

CFTR Tclin Cystic fibrosis transmembrane conductance regulator (3 Activities)

Discover Target: CFTR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)