TP-238 hydrochloride - ≥98% , CAS No.2415263-05-5

CAS: 2415263-05-5 Cat. No.: T648473 Molecular Weight: 495.04 PubChem CID: 146018950

GRADE & PURITY ≥98%

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview

TP-238 hydrochloride is a potent and selective dual CECR2/BPTF probe with IC 50 values of 30 nM and 350 nM, respectively. TP-238 hydrochloride also inhibits BRD9 with a pIC 50 of 5.9 and is less active against other 338 kinases

In Vitro

TP-238 has on target biochemical activity of 10-30 nM with CECR2 and 100-350 nM with BPTF. TP-238 displays potency for both CECR2 (pIC50 of 7.5) and BPTF (pIC50 of 6.5) in an Alpha screen assay. Isothermal titration calorimetry (ITC) shows TP-238 with a Kd of 10 nM for CECR2 and 120 nM for BPTF . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:CECR2|30 nM (IC|50|)|CECR2|10 nM (Kd)|CECR2|7.5 (pIC|50|)|BPTF|350 nM (IC|50|)|BPTF|120 nM (Kd)|BPTF|6.5 (pIC|50|)|BRD9|5.9 (pIC|50|)

Specifications

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

TP-238 hydrochloride is a potent and selective dual CECR2/BPTF probe with IC 50 values of 30 nM and 350 nM, respectively. TP-238 hydrochloride also inhibits BRD9 with a pIC 50 of 5.9 and is less active against other 338 kinases.

Storage

Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Canonical Smiles: CN(C)CCCOC1=CC=C(C=C1)C2=CC(=NC(=N2)S(=O)(=O)C)NCCCN3C=CC=N3.Cl
• IUPAC Name: 6-[4-[3-(dimethylamino)propoxy]phenyl]-2-methylsulfonyl-N-(3-pyrazol-1-ylpropyl)pyrimidin-4-amine;hydrochloride
• InChIKey: FHVADRKEPFRFFF-UHFFFAOYSA-N
• INCHI: 1S/C22H30N6O3S.ClH/c1-27(2)13-6-16-31-19-9-7-18(8-10-19)20-17-21(26-22(25-20)32(3,29)30)23-11-4-14-28-15-5-12-24-28;/h5,7-10,12,15,17H,4,6,11,13-14,16H2,1-3H3,(H,23,25,26);1H
• PubChem CID: 146018950
• Molecular Weight: 495.04

Chemical and Physical Properties

• Solubility: DMSO : 100 mg/mL (202.00 mM; Need ultrasonic)