Tyrphostin A1 - Moligand™, 10 mM in DMSO , CAS No.2826-26-8

CAS: 2826-26-8 Cat. No.: T1498599 Molecular Weight: 184.2 EC Number: 808-183-6 PubChem CID: 2063

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Tyrphostin A1(AG9) inhibits CD40L-stimulated IL-12 production in macrophage cultures and antigen-induced generation of Th1 cells.IC50 value: Target: IL-12 production inhibitorAddition of increasing concentration of A1 resulted in a dose dependent decrease of IL-12 p40, with maximal inhibition (62.5%) occurring at a dose of 10 μM. tyrphostin A1 blocks CD40L-induced translocation of NF-κB to the nucleus, and reduces the activation of IL-12 p40 gene. In vivo therapy with A1 leads to decrease in generation of myelin basic protein (MBP) specific encephalitogenic T cells. In addition, treatment of SJL/J mice with A1 results in attenuation of experimental allergic encephalomyelitis (EAE) . Tyrphostin A1 is a much weaker inhibitor of TK than other tyrphostins (IC50>1250 μM for epidermal growth factor receptor ( EGFR ) kinase), and therefore often used to differentiate TK-mediated effects of tyrphostins from other non-specific effects .

Specifications

Specifications & Purity

Moligand™, 10 mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Names and Identifiers

• Isomeric SMILES: COC1=CC=C(C=C1)C=C(C#N)C#N
• WGK Germany: 3
• PubChem CID: 2063
• Molecular Weight: 184.2

Chemical and Physical Properties

• Melt Point(°C): 115 °C