10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
YAP/TAZ inhibitor-2 is a potent and orally active TEAD-YAP/TAZ inhibitor with an EC 50 value of 3 nM. YAP/TAZ inhibitor-2 shows anti-proliferative activity. YAP/TAZ inhibitor-2 shows antitumor activity
In Vitro
YAP/TAZ inhibitor-2 (compound 5) (0-20000 nM; 24 h) shows antiproliferative activity with an IC 50 value of 5.33 nM in NCI-H226 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
YAP/TAZ inhibitor-2 (0.5, 2, 5, 50 mg/kg; p.o.; daily for 28 days) shows anti-tumor activity with no significant body weight loss during the treatment in BALB/c nude mice (NCI-H226 xenograft model) . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
IC50& Target:EC 50 : 3 nM (TEAD-YAP/TAZ)
Specifications
Specifications & Purity
10mM in DMSO
Biochemical and Physiological Mechanisms
YAP/TAZ inhibitor-2 is a potent and orally active TEAD-YAP/TAZ inhibitor with an EC 50 value of 3 nM. YAP/TAZ inhibitor-2 shows anti-proliferative activity. YAP/TAZ inhibitor-2 shows antitumor activity.
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Names and Identifiers
Molecular Weight
390.33
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
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