Z 944 - Moligand™, ≥98%(HPLC) , Channel blocker of Ca v3.1;Channel blocker of Ca v3.2;Channel blocker of Ca v3.3, CAS No.1199236-64-0, Channel blocker of Ca v3.1;Channel blocker of Ca v3.2;Channel blocker of Ca v3.3

CAS: 1199236-64-0 Cat. No.: Z288507 Fórmula: C₁₉H₂₇ClFN₃O₂ Peso molecular: 383.89 PubChem CID: 44540045

GRADE & PURITY Moligand™, ≥98%(HPLC)

Synonyms

4-(((3-Chloro-5-fluorobenzoyl)amino)methyl)-N-(1,1-dimethylethyl)-1-piperidineacetamide | PRAX944 | PRAX-944 | PTFE rod, 3.18mm (0.125in) dia | BDBM50192689 | 1199236-64-0 | 4-[[(3-Chloro-5-fluorobenzoyl)amino)methyl]-N-(1,1-dimethylethyl)-1-piperidineace

Storage

Conservar a -20°C

Shipped In

Hielera + almohadillas de hielo

Descripción general

Introducción del producto

Z944 es un bloqueante de los canales de calcio de tipo T. Z944 retrasa la progresión de las convulsiones en el modelo kindling de la amígdala. Z944 altera la inhibición del prepulso en ratas epilépticas y no epilépticas.

Specifications

Sinónimos

4-(((3-Chloro-5-fluorobenzoyl)amino)methyl)-N-(1,1-dimethylethyl)-1-piperidineacetamide | PRAX944 | PRAX-944 | PTFE rod, 3.18mm (0.125in) dia | BDBM50192689 | 1199236-64-0 | 4-[[(3-Chloro-5-fluorobenzoyl)amino)methyl]-N-(1,1-dimethylethyl)-1-piperidineace

Especificaciones y pureza

Moligand™, ≥98%(HPLC)

Mecanismos bioquímicos y fisiológicos

Bloqueante selectivo de los canales de Ca2+ de tipo T (valores IC50 de 50 a 160 nM para hCav3.1, hCav3.2 y hCav3.3). Presenta una selectividad de 50 a 600 veces para los canales Cav3.x sobre los canales iónicos relacionados (Cav1.2, hERG y Nav1.5). No afe

Condiciones de almacenamiento de almacenamiento

Conservar a -20°C

Enviado en

Hielera + almohadillas de hielo

Grado

Moligand™

Tipo de acción

CHANNEL BLOCKER

Mecanismo de acción

Channel blocker of Ca v3.1;Channel blocker of Ca v3.2;Channel blocker of Ca v3.3

Pureza

≥98%(HPLC)

Nombres e identificadores

• Pubchem Sid: 504770363
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504770363
• Sonrisas canónicas: CC(C)(C)NC(=O)CN1CCC(CC1)CNC(=O)C2=CC(=CC(=C2)Cl)F
• IUPAC Name: N-[[1-[2-(tert-butylamino)-2-oxoethyl]piperidin-4-yl]methyl]-3-chloro-5-fluorobenzamide
• InChIKey: JOCLITFYIMJMNK-UHFFFAOYSA-N
• INCHI: 1S/C19H27ClFN3O2/c1-19(2,3)23-17(25)12-24-6-4-13(5-7-24)11-22-18(26)14-8-15(20)10-16(21)9-14/h8-10,13H,4-7,11-12H2,1-3H3,(H,22,26)(H,23,25)
• Isómeros SMILES: CC(C)(C)NC(=O)CN1CCC(CC1)CNC(=O)C2=CC(=CC(=C2)Cl)F
• PubChem CID: 44540045
• Peso molecular: 383.89

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Clase Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 Alpha amino acid amides

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Clase: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives
• Direct Parent: Alpha amino acid amides
• Alternative Parents: 3-halobenzoic acids and derivatives Benzamides Benzoyl derivatives Chlorobenzenes Fluorobenzenes Aryl chlorides Piperidines Aryl fluorides Trialkylamines Secondary carboxylic acid amides Azacyclic compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds Organochlorides Organofluorides
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Alpha-amino acid amide - 3-halobenzoic acid or derivatives - Halobenzoic acid or derivatives - Benzamide - Benzoic acid or derivatives - Benzoyl - Chlorobenzene - Fluorobenzene - Halobenzene - Aryl chloride - Aryl fluoride - Aryl halide - Monocyclic benzene moiety - Benzenoid - Piperidine - Tertiary aliphatic amine - Tertiary amine - Secondary carboxylic acid amide - Carboxamide group - Organoheterocyclic compound - Azacycle - Organofluoride - Organic oxide - Carbonyl group - Organic oxygen compound - Amine - Hydrocarbon derivative - Organic nitrogen compound - Organonitrogen compound - Organooxygen compound - Organohalogen compound - Organochloride - Aromatic heteromonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as alpha amino acid amides. These are amide derivatives of alpha amino acids.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

CACNA1H Tclin Voltage-dependent T-type calcium channel subunit alpha-1H (3 Activities)

Discover Target: CACNA1H

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CACNA1G Tclin Voltage-dependent T-type calcium channel subunit alpha-1G (3 Activities)

Discover Target: CACNA1G

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CACNA1I Tclin Voltage-dependent T-type calcium channel subunit alpha-1I (3 Activities)

Discover Target: CACNA1I

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CACNA1H Tclin Voltage-gated T-type calcium channel alpha-1H subunit (1913 Activities)

Discover Target: CACNA1H

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Objetivos asociados (no humanos)

Cacna1g Voltage-gated T-type calcium channel alpha-1G subunit (1 Activities)

Discover Target: Cacna1g

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: Solvent:DMSO, Max Conc. mg/mL: 38.39, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 38.39, Max Conc. mM: 100
• Punto de fusión (°C): 122-124°C
• Peso molecular: 383.900 g/mol
• XLogP3: 3.000
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 383.178 Da
• Monoisotopic Mass: 383.178 Da
• Topological Polar Surface Area: 61.400 Ų
• Heavy Atom Count: 26
• Formal Charge: 0
• Complexity: 490.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Preguntas frecuentes

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

What is the purity of this product, and how is it determined?

This product is supplied at ≥98% purity, determined by HPLC. Lot-specific values are stated on the Certificate of Analysis.

What is Moligand??

Moligand? is one of Aladdin Scientific's premium product lines, formulated for high-purity applications across multiple workflows. Compared to standard grades in the same workflow, Moligand? products typically offer tighter specifications, more rigorous QC, and stronger lot-to-lot consistency.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1199236-64-0, the molecular formula is C19H27ClFN3O2, and the molecular weight is 383.89 g/mol. InChIKey JOCLITFYIMJMNK-UHFFFAOYSA-N.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.