(-)-ZK 216348 - ≥98% , CAS No.Z659207

CAS: Z659207 Cat. No.: Z659207 Molecular Weight: 476.45

GRADE & PURITY ≥98%

Storage

Store at 2-8°C,Protected from light,Desiccated

Shipped In

Wet ice

Overview

(-)-ZK 216348 is the enantiomer of (+)-ZK 216348 ( HY-123352 ). (+)-ZK 216348 is a nonsteroidal selective glucocorticoid receptor agonist with an IC 50 of 20.3 nM. ZK 216348 also binds to Progesterone and mineralocorticoid receptors with IC 50 s of 20.4 n

Appearance:Solid

IC50& Target:IC50: 20.3 nM (Glucocorticoid recepto), 20.4 nM (Progesterone receptor ) and 79.9 nM (mineralocorticoid receptor)

In Vitro:In human peripheral blood mononuclear cells (PBMCs), ZK 216348 inhibits TNF-α and IL-12 with IC 50 of 89 nM and 52 nM, respectively. Participation of an active GR in the antiinflammatory response of ZK 216348 is further investigated in Caco-2 cells,

In Vivo:ZK 216348 (1-30mg/kg; subcutaneous injection; for 24 hours; NMRI mice and Wistar rats) treatment inhibits ear edema in both mice and rats. A markedly superior side-effect profile is found in ZK 216348 with regard to increases in blood glucose, spleen inv

Biological Activity:(-)-ZK 216348 is the enantiomer of (+)-ZK 216348 ( HY-123352 ). (+)-ZK 216348 is a nonsteroidal selective glucocorticoid receptor agonist with an IC 50 of 20.3 nM. ZK 216348 also binds to Progesterone and mineralocorticoid receptors with IC 50 s of 20.4 n

Specifications

Specifications & Purity

≥98%

Storage

Store at 2-8°C, Protected from light, Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

AGONIST

Purity

≥98%

Names and Identifiers

• Molecular Weight: 476.45

Chemical and Physical Properties

• Solubility: DMSO : 230 mg/mL (482.74 mM; Need ultrasonic)