ZK168281 - ≥98% , CAS No.186371-96-0

CAS: 186371-96-0 Cat. No.: Z646816 Molecular Weight: 510.70

GRADE & PURITY ≥98%

Storage

Store at 2-8°C,Protected from light,Argon charged

Shipped In

Wet ice

Overview

ZK168281 is a 25-carboxylic ester 1α,25(OH) 2 D 3 analog and a pure VDR antagonist with a K d value of 0.1 nM. ZK168281 is an effective inhibitor of the coactivator (CoA) interaction of its receptor

In Vitro

ZK168281 resembles more the mouse constitutive androstane receptor (CAR) inverse agonist Androstanol in its ability to recruit corepressor (CoR) proteins. A salt bridge between the CoR and a conserved lysine in helix 4 of the nuclear receptor (NR) is central to this interaction, but also helix 12 was stabilized by direct contacts with residues of the CoR. Fixation of helix 12 in the antagonistic/inverse agonistic conformation prevents an energetically unfavorable free floatation of the C terminus. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:Kd: 0.1 nM (VDR)

Specifications

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

ZK168281 is a 25-carboxylic ester 1α, 25(OH) 2 D 3 analog and a pure VDR antagonist with a K d value of 0.1 nM. ZK168281 is an effective inhibitor of the coactivator (CoA) interaction of its receptor.

Storage

Store at 2-8°C, Protected from light, Argon charged

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Molecular Weight: 510.70

Chemical and Physical Properties

• Solubility: DMSO : 100 mg/mL (195.81 mM; Need ultrasonic)