10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Desiccated,Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
ZM223 hydrochloride is an orally active, potent non-covalent NEDD8 activating enzyme ( NAE ) inhibitor with excellent anticancer activity.
IC50& Target:NEDD8 activating enzyme (NAE)
In Vitro:ZM223 hydrochloride (0.1-1 μM; 4 hours) inhibits both HCT-116 and U-2OS cancer cells with IC 50 s of 100 and 122 nM, respectively. ZM223 hydrochloride (0.1-1 μM; 4 hours) causes a dose-response decrease in the level of NEDD8 and accumulation of the U
Biological Activity:ZM223 hydrochloride is an orally active, potent non-covalent NEDD8 activating enzyme ( NAE ) inhibitor with excellent anticancer activity.
Specifications
Specifications & Purity
10mM in DMSO
Storage
Desiccated, Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
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