100mM Pro-Ac, 20 mM Arg, pH 5.0 buffer - BioReagent,Suitable for molecular biology,sterile,100mM Pro-Ac, 20 mM Arg

Cat. No.: M1455181

GRADE & PURITY Suitable for molecular biology, BioReagent, Sterile, 100mM Pro-Ac, 20 mM Arg

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Pro-Ac (proline acetate) buffer is mainly used as an optimized stabilizing buffer system in biopharmaceuticals, especially for the reconstitution of antibody-drug conjugates (ADCs) and the storage of antibodies. Its standard formulation is typically 100 mM Pro-Ac, 20 mM Arg, pH 5.0.In ADC reconstitution, this buffer protects the chemical stability of linkers (such as cleavable linkers) by maintaining an acidic environment at pH 5.0, slowing down hydrolysis. Through the synergistic effects of proline and arginine (e.g., enhancing hydration and inhibiting protein-protein interactions), it reduces antibody aggregation, controls solution viscosity, and preserves antibody conformation. In antibody storage, Pro-Ac buffer effectively improves the colloidal stability and long-term storage stability of antibodies. The proline contained in it also acts as a natural cryoprotectant, protecting protein structures during freeze-thaw cycles. Compared with traditional buffers (such as acetate or histidine buffers), Pro-Ac provides superior stabilization for ADCs and antibodies around pH 5.0.

Specifications

Specifications & Purity

BioReagent, Suitable for molecular biology, sterile, 100mM Pro-Ac, 20 mM Arg

Stability And Storage

Store at -80℃ for 12 months.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

BioReagent, Sterile, Suitable for molecular biology

Names and Identifiers

• PH: 5.0±0.1