2',3'-cGAMP Sodium Salt - Moligand™, ≥98% , Agonist of stimulator of interferon response cGAMP interactor 1, CAS No.2734858-36-5, Agonist of stimulator of interferon response cGAMP interactor 1

CAS: 2734858-36-5 Cat. No.: C413868 Molecular Weight: 718.37

GRADE & PURITY Moligand™, ≥98%

Synonyms

2/'3/'-cGAMP | cyclic [G(2',5')pA(3',5')p] | UNII-552Y49K43E | J3.180.146J | 2',5'-3',5'-cGAMP | 2'-3'-cyclic GMP-AMP;2',3'-cGAMP | 2-Amino-9-((5R,7R,8R,12aR,14R,15R,15aS,16R)-14-(6-amino-9H-purin-9-yl)-2,10,15,16-tetrahydroxy-2,10-dioxidooctahydro-12H-5,

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Information

2',3'-cGAMP Sodium Salt 2',3'-cGAMP Sodium Salt (2'-3'-cyclic GMP-AMP Sodium) is produced in response to DNA in the cytoplasm in mammalian cells and binds STING with high affinity and is an effective inducer of interferon-β (IFNβ) . 2',3'-cGAMP binds to STING with Kd of 3.79 nM.

Targets

STING (Cell-free assay) 3.79 nM(Kd)

In vitro

2\',3\'-cGAMP is an endogenous second messenger produced by mammalian cells. 2\',3\'-cGAMP is a high affinity ligand for STING. 2\',3\'-cGAMP is a potent inducer of type-I interferons. 2\',3\'-cGAMP binding induces conformational changes of STING.

Cell Research(from reference)

Cell lines：A549, BSC-40, BSR-T7, Vero cells 

Concentrations：25 μM, 20 μM, 2.5 μM 

Incubation Time：30 min 

Specifications

Synonyms

2/'3/'-cGAMP | cyclic [G(2', 5')pA(3', 5')p] | UNII-552Y49K43E | J3.180.146J | 2', 5'-3', 5'-cGAMP | 2'-3'-cyclic GMP-AMP;2', 3'-cGAMP | 2-Amino-9-((5R, 7R, 8R, 12aR, 14R, 15R, 15aS, 16R)-14-(6-amino-9H-purin-9-yl)-2, 10, 15, 16-tetrahydroxy-2, 10-dioxidooctahydro-12H-5,

Specifications & Purity

Moligand™, ≥98%

Biochemical and Physiological Mechanisms

2', 3'-cGAMP Sodium Salt (2'-3'-cyclic GMP-AMP Sodium) is produced in response to DNA in the cytoplasm in mammalian cells and binds STING with high affinity and is an effective inducer of interferon-β (IFNβ). 2', 3'-cGAMP binds to STING with Kd of 3.79 nM.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

AGONIST

Mechanism of action

Agonist of stimulator of interferon response cGAMP interactor 1

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 504773384
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504773384
• Alternate CAS: 1441190-66-4
• Molecular Weight: 718.37

Associated Targets(Human)

TMEM173 Tchem Stimulator of interferon genes protein (8 Activities)

Discover Target: TMEM173

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

THP-1 (11052 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Monocyte (474 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ENPP1 Tchem Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (635 Activities)

Discover Target: ENPP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MC-38 (857 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Irf3 Interferon regulatory factor 3 (2 Activities)

Discover Target: Irf3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Sting1 Stimulator of interferon genes protein (255 Activities)

Discover Target: Sting1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Nuclease P1 (7 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro Water: 50 mg/mL (69.6 mM); DMSO: 12.5 mg/mL (17.4 mM)
• Sensitivity: Moisture sensitive.
• Molecular Weight: 674.400 g/mol
• XLogP3: -5.900
• Hydrogen Bond Donor Count: 7
• Hydrogen Bond Acceptor Count: 19
• Rotatable Bond Count: 2
• Exact Mass: 674.1 Da
• Monoisotopic Mass: 674.1 Da
• Topological Polar Surface Area: 325.000 Ų
• Heavy Atom Count: 45
• Formal Charge: 0
• Complexity: 1300.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 8
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1