10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
AKT Kinase Inhibitor is an Akt kinase inhibitor with anti-tumor activity.
In Vitro
The effect of selective inhibition of Akt in proliferating cells expressing Trop-2 is studied. Akt inhibition, either by silencing or with specific drugs, induces a marked decrease in cell proliferation in cells expressing Trop-2, in a dose-dependent fashion. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Trop-2 expressing tumors subcutaneously injected in animal models show a striking reduction of growth following treatment with specific drugs that inhibit Akt activity. Therefore Akt has a central functional role in mediating the Trop-2-dependent growth stimulus . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Isomeric SMILES | CCN1C2=C(C(=NC=C2OCCCN)C#CCO)N=C1C3=NON=C3N |
|---|---|
| Alternate CAS | 842148-40-7 |
| PubChem CID | 25023726 |
| Molecular Weight | 357.37 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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View spec sheet →| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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