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Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Aspochalasin D is a co-metabolite originally isolated from A. microcysticus with aspochalasins A, B, and C, that is initially thought to be inactive. It has antibacterial activity against Gram-positive and Gram-negative bacteria at a concentration of 1 mg/ml.2 Aspochalasin D is more cytotoxic, via apoptosis , to Ba/F3-V12 cells in an IL-3-free medium than in an IL-3-containing medium ( IC 50 s=0.49 and 1.9 μg/mL, respectively).
| Canonical Smiles | CC1C2C(NC(=O)C23C(C=C(CCC(C(C=CC3=O)O)O)C)C=C1C)CC(C)C |
|---|---|
| IUPAC Name | (1S,3Z,5S,6R,9Z,11S,14S,15R,16S)-5,6-dihydroxy-9,13,14-trimethyl-16-(2-methylpropyl)-17-azatricyclo[9.7.0.01,15]octadeca-3,9,12-triene-2,18-dione |
| InChIKey | GCIKKGSNXSCKCP-IJDGJKBTSA-N |
| INCHI | 1S/C24H35NO4/c1-13(2)10-18-22-16(5)15(4)12-17-11-14(3)6-7-19(26)20(27)8-9-21(28)24(17,22)23(29)25-18/h8-9,11-13,16-20,22,26-27H,6-7,10H2,1-5H3,(H,25,29)/b9-8-,14-11-/t16-,17+,18+,19-,20+,22+,24-/m1/s1 |
| Isomeric SMILES | C[C@H]1[C@H]2[C@@H](NC(=O)[C@@]23[C@@H](/C=C(\CC[C@H]([C@H](/C=C\C3=O)O)O)/C)C=C1C)CC(C)C |
| Alternate CAS | 71968-02-0 |
| PubChem CID | 6440506 |
| MeSH Entry Terms | aspochalasin D |
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