Atglistatin - ≥98% , CAS No.1469924-27-3

CAS: 1469924-27-3 Cat. No.: A302918 Molecular Weight: 283.37 EC Number: 809-205-7

GRADE & PURITY ≥98%

Synonyms

AKOS026750242 | HY-15859 | FT-0700208 | SW220102-1 | AC-35213 | EN300-172737 | 3-(4'-(dimethylamino)biphenyl-3-yl)-1,1-dimethylurea | s7364 | AWOPBSAJHCUSAS-UHFFFAOYSA-N | NCGC00261484-01 | 1-[4'-(DIMETHYLAMINO)-[1,1'-BIPHENYL]-3-YL]-3,3-DIMETHYLUREA | 3-

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

Synonyms

AKOS026750242 | HY-15859 | FT-0700208 | SW220102-1 | AC-35213 | EN300-172737 | 3-(4'-(dimethylamino)biphenyl-3-yl)-1, 1-dimethylurea | s7364 | AWOPBSAJHCUSAS-UHFFFAOYSA-N | NCGC00261484-01 | 1-[4'-(DIMETHYLAMINO)-[1, 1'-BIPHENYL]-3-YL]-3, 3-DIMETHYLUREA | 3-

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Atglistatin is the first drug to selectively inhibit adipotriglyceride lipase (ATGL), a rate limiting enzyme involved in the mobilization of fatty acids from cellular triglyceride stores. The IC50 of atglistatin was 0.7 μ m in E. coli, and it had no activ

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 504772197
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504772197
• Canonical Smiles: CN(C)C1=CC=C(C=C1)C2=CC(=CC=C2)NC(=O)N(C)C
• IUPAC Name: 3-[3-[4-(dimethylamino)phenyl]phenyl]-1,1-dimethylurea
• InChIKey: AWOPBSAJHCUSAS-UHFFFAOYSA-N
• INCHI: 1S/C17H21N3O/c1-19(2)16-10-8-13(9-11-16)14-6-5-7-15(12-14)18-17(21)20(3)4/h5-12H,1-4H3,(H,18,21)
• Isomeric SMILES: CN(C)C1=CC=C(C=C1)C2=CC(=CC=C2)NC(=O)N(C)C
• Molecular Weight: 283.37
• Reaxy-Rn: 29267490
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=29267490&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Benzene and substituted derivatives
      • Subclass Biphenyls and derivatives

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Benzene and substituted derivatives
• Subclass: Biphenyls and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Biphenyls and derivatives
• Alternative Parents: N-phenylureas Dialkylarylamines Aniline and substituted anilines Ureas Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Biphenyl - N-phenylurea - Tertiary aliphatic/aromatic amine - Dialkylarylamine - Aniline or substituted anilines - Tertiary amine - Urea - Amine - Organic oxide - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Carbonyl group - Organic nitrogen compound - Hydrocarbon derivative - Aromatic homomonocyclic compound
• Description: This compound belongs to the class of organic compounds known as biphenyls and derivatives. These are organic compounds containing to benzene rings linked together by a C-C bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

PNPLA2 Tchem Patatin-like phospholipase domain-containing protein 2 (1 Activities)

Discover Target: PNPLA2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Pnpla2 Patatin-like phospholipase domain-containing protein 2 (302 Activities)

Discover Target: Pnpla2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: DMSO: 20 mg/mL, clear
• Molecular Weight: 283.370 g/mol
• XLogP3: 3.300
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 283.168 Da
• Monoisotopic Mass: 283.168 Da
• Topological Polar Surface Area: 35.600 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 335.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Jian Chen, Zhixiang Wei, Zixuan Song, Sitong Meng, Jiaqi An, Zhenqun Zhang, Yaning Biao, Muqing Zhang, Yixin Zhang.  (2026)  Atractylodin ameliorates obesity-associated hepatic steatosis by regulating the PLIN2-ATGL/CPT1A axis-mediated lipid droplet-mitochondria interactions.  PHYTOMEDICINE,      [PMID:] [10.1016/j.phymed.2026.158134]