Bax activator-1 - ≥98% , CAS No.1638526-94-9

CAS: 1638526-94-9 Cat. No.: B647935 Molecular Weight: 488.62 PubChem CID: 26230248

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Bax activator-1 (compound 106) is a Bax activator that induces Bax-dependent tumor cell apoptosis

In Vitro

Bax activator-1 (20-80 μM; 48 hours) induces Bax-dependent tumor cell apoptosis in a dose-dependent fashion. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Apoptosis AnalysisCell Line: Lewis Lung Carcinoma tumor cells, human non-small cell lung carcinoma A549 cells, human pancreatic carcinoma Panc-1 cells Concentration: 20 μM, 40 μM , 60 μM , 80 μM Incubation Time: 48 hours Result: Induced apoptotic cell death in the murine Lewis Lung Carcinoma (LLC), human non-small cell lung carcinoma A549 cells and PANC-1 human pancreatic carcinoma cells in a dose-dependent fashion.

In Vivo

Bax activator-1 (40 mg/kg; given i.p., each day for 13 days) inhibits lung tumor growth in C57BL/6 female mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Eight-week old C57BL/6 female mice (with Lewis Lung Carcinoma tumor cells) Dosage: 40 mg/kg Administration: Given i.p., each day for 13 days Result: Exhibited anti-tumor activity as a single-agent.

Form:Solid

IC50& Target:Bax

Specifications

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Bax activator-1 (compound 106) is a Bax activator that induces Bax-dependent tumor cell apoptosis.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

ACTIVATOR

Purity

≥98%

Names and Identifiers

• Canonical Smiles: CC1=C(C=C(C=C1)CN2CCC3=C(C2)C(=NN3CC4=CC(=CC=C4)OC)C(=O)N5CCCC(C5)O)C
• IUPAC Name: [5-[(3,4-dimethylphenyl)methyl]-1-[(3-methoxyphenyl)methyl]-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-3-yl]-[(3R)-3-hydroxypiperidin-1-yl]methanone
• InChIKey: OLNVSYZSZXRLCF-XMMPIXPASA-N
• INCHI: 1S/C29H36N4O3/c1-20-9-10-23(14-21(20)2)16-31-13-11-27-26(19-31)28(29(35)32-12-5-7-24(34)18-32)30-33(27)17-22-6-4-8-25(15-22)36-3/h4,6,8-10,14-15,24,34H,5,7,11-13,16-19H2,1-3H3/t24-/m1/s1
• Isomeric SMILES: CC1=C(C=C(C=C1)CN2CCC3=C(C2)C(=NN3CC4=CC(=CC=C4)OC)C(=O)N5CCC[C@H](C5)O)C
• PubChem CID: 26230248
• Molecular Weight: 488.62

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Piperidines
      • Subclass N-acylpiperidines

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Piperidines
• Subclass: N-acylpiperidines
• Intermediate Tree Nodes: Not available
• Direct Parent: N-acylpiperidines
• Alternative Parents: 2-heteroaryl carboxamides Anisoles Benzylamines Methoxybenzenes Phenoxy compounds Phenylmethylamines Pyrazole-5-carboxamides o-Xylenes Alkyl aryl ethers Aralkylamines Tertiary carboxylic acid amides Heteroaromatic compounds Amino acids and derivatives Secondary alcohols Trialkylamines Azacyclic compounds Hydrocarbon derivatives Organic oxides
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: N-acyl-piperidine - Phenylmethylamine - Phenol ether - 2-heteroaryl carboxamide - Methoxybenzene - Benzylamine - Pyrazole-5-carboxamide - Xylene - O-xylene - Phenoxy compound - Anisole - Aralkylamine - Alkyl aryl ether - Monocyclic benzene moiety - Benzenoid - Tertiary carboxylic acid amide - Azole - Pyrazole - Heteroaromatic compound - Amino acid or derivatives - Carboxamide group - Tertiary aliphatic amine - Tertiary amine - Secondary alcohol - Ether - Carboxylic acid derivative - Azacycle - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Amine - Organonitrogen compound - Organooxygen compound - Alcohol - Organic oxygen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as n-acylpiperidines. These are compounds containing an N-acyethanolamine moiety, which is characterized by an acyl group is linked to the nitrogen atom of a piperidine.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: DMSO : 250 mg/mL (511.65 mM; Need ultrasonic)