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CH7233163 - ≥98% , CAS No.C414469

CH7233163 - ≥98% , CAS No.C414469

CAS: C414469 Cat. No.: C414469 Molecular Weight: 669.72

COA

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AVAILABLE TO ORDER

GRADE & PURITY ≥98%

Synonyms

N-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-5-isopropyl-7-(4-methylpiperazin-1-yl)-9-(2,2,2-trifluoroethoxy)-5H-pyrido[4,3-b]indol-3-amine

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview Specifications Names and Identifiers Documentation Advanced Data Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solution Calculators Reviews

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Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Information

CH7233163 is a non-covalent ATP competitive inhibitor ofEGFR-tyrosine kinasewith antitumor activities against tumor with EGFR-Del19/T790M/C797S.

Targets

EGFR

In vitro

CH7233163 shows potent antitumor activities against tumor with EGFR-Del19/T790M/C797S in vitro. CH7233163 potently inhibits the proliferation of Del19/T790M/C797S_NIH3T3 cells with IC50 of 20 nmol/L. CH7233163 potently and dose-dependently blocks the EGFR phosphorylation in the Del19/T790M/C797S_NIH3T3 cells. CH7233163 can inhibit Del19/T790M/C797S signaling.

In vivo

Pharmacodynamic study is performed using Del19/T790M/C797S_NIH3T3 xenografted tumors in mice. CH7233163 clearly inhibits EGFR phosphorylation after oral administration and potent tumor regression is observed. CH7233163 has potent therapeutic efficacy against tumors with EGFR-Del19/T790M/C797S in vivo.

Cell Research(from reference)

Cell lines：NIH3T3 cells (ATCC)

Concentrations：8 nM, 40 nM, 200 nM, 1000 nM

Incubation Time：0.5 h-24 h, 4-7 days

Specifications

Synonyms

N-(2-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)pyrimidin-4-yl)-5-isopropyl-7-(4-methylpiperazin-1-yl)-9-(2, 2, 2-trifluoroethoxy)-5H-pyrido[4, 3-b]indol-3-amine

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

CH7233163 is a non-covalent ATP competitive inhibitor of EGFR-tyrosine kinase with antitumor activities against tumor with EGFR-Del19/T790M/C797S.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥98%

Names and Identifiers

Molecular Weight	669.72

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

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✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

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📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

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Advanced Data

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 100 mg/mL (149.31 mM); Water: Insoluble; Ethanol: Insoluble;

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