≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Cyclo(RGDyK) Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.
Targets
αVβ3 integrin 20 nM
In vitro
Cyclo(RGDyK) shows high affinity and selectivity for αVβ3 over αVβ5 and αIIbβ3. Cyclo(RGDyK)-conjugated micelles (TPM) facilitated the cell-specific uptake of DiI into B16-F10 cells and HUVECs via integrin-mediated endocytosis compared with Cyclo(RGDyK) -free micelles (NPM).
In vivo
In apoE−/− mice, Cyclo(RGDyK) (1 nmol, i.v.) inhibits the increase of αVβ3 integrin expression in the intima of the left stenotic carotid artery.
| ALogP | -3.67 |
|---|---|
| HBD Count | 10 |
| Rotatable Bond | 14 |
| Pubchem Sid | 504773062 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504773062 |
| Canonical Smiles | C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCN=C(N)N)CCCCN)CC2=CC=C(C=C2)O)CC(=O)O.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O |
| IUPAC Name | 2-[(2S,5R,8S,11S)-8-(4-aminobutyl)-11-[3-(diaminomethylideneamino)propyl]-5-[(4-hydroxyphenyl)methyl]-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid;2,2,2-trifluoroacetic acid |
| InChIKey | CDDUWKKOPQABPG-TVSMIREGSA-N |
| INCHI | 1S/C27H41N9O8.2C2HF3O2/c28-10-2-1-4-18-24(42)34-17(5-3-11-31-27(29)30)23(41)32-14-21(38)33-20(13-22(39)40)26(44)36-19(25(43)35-18)12-15-6-8-16(37)9-7-15;2*3-2(4,5)1(6)7/h6-9,17-20,37H,1-5,10-14,28H2,(H,32,41)(H,33,38)(H,34,42)(H,35,43)(H,36,44)(H,39,40)(H4,29,30,31);2*(H,6,7)/t17-,18-,19+,20-;;/m0../s1 |
| PubChem CID | 129896716 |
| Molecular Weight | 847.72 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 K2215399 | Certificate of Analysis | Aug 18, 2025 | C413850 |
| K2215398 | Certificate of Analysis | Aug 18, 2025 | C413850 |
| K2215397 | Certificate of Analysis | Aug 18, 2025 | C413850 |
| K2215391 | Certificate of Analysis | Aug 18, 2025 | C413850 |
| C2508079 | Certificate of Analysis | Aug 10, 2022 | C413850 |
| Solubility | Solubility (25°C) In vitro DMSO: 100 mg/mL (117.96 mM); Water: 100 mg/mL (117.96 mM); Ethanol: Insoluble; |
|---|---|
| Sensitivity | Moisture sensitive |
| DMSO(mg / mL) Max Solubility | 100 |
| DMSO(mM) Max Solubility | 117.9634785 |
| Water(mg / mL) Max Solubility | 100 |
| Water(mM) Max Solubility | 117.9634785 |
| Molecular Weight | 847.700 g/mol |
| XLogP3 | |
| Hydrogen Bond Donor Count | 12 |
| Hydrogen Bond Acceptor Count | 20 |
| Rotatable Bond Count | 12 |
| Exact Mass | 847.294 Da |
| Monoisotopic Mass | 847.294 Da |
| Topological Polar Surface Area | 368.000 Ų |
| Heavy Atom Count | 58 |
| Formal Charge | 0 |
| Complexity | 1130.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 4 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 3 |
