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· · COA & SDS available for every product · Same-day shipping on in-stock items Danoprevir - ≥95% , Hepatitis C virus serine protease, NS3/NS4A inhibitor, CAS No.850876-88-9, Hepatitis C virus serine protease, NS3/NS4A inhibitor
Synonyms
Ganovo | R7227 | UNII-911Z9PCQ5F | CCG-270417 | Danoprevir (ITMN-191) | (3S,5R,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid | BIDD:GT0614 | DANOPREVIR [INN] | ITMN B | 4-Fluoro-1,3-dihydro-2h-isoindole-2-carboxyl
Shipped In
Ice chest + Ice pads
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Why this grade ≥95% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Specifications Synonyms
Ganovo | R7227 | UNII-911Z9PCQ5F | CCG-270417 | Danoprevir (ITMN-191) | (3S, 5R, 6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3, 5-dihydroxyhept-6-enoic acid | BIDD:GT0614 | DANOPREVIR [INN] | ITMN B | 4-Fluoro-1, 3-dihydro-2h-isoindole-2-carboxyl
Specifications & Purity
≥95%
Biochemical and Physiological Mechanisms
Danoprevir(ITMN 191; ITMN-191; R7227; RO5190591; RG7227) is an inhibitor of the NS3/4A protease.Danoprevir (ITMN 191; ITMN-191; R7227; RO5190591; RG7227)is useful for anti-HCV, anti-cancer.Potent orally available peptidomimetic inhibitor of the NS3/4A prot
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Mechanism of action
Hepatitis C virus serine protease, NS3/NS4A inhibitor
Product Properties Names and Identifiers Pubchem Sid 504766246 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504766246 Canonical Smiles CC(C)(C)OC(=O)NC1CCCCCC=CC2CC2(NC(=O)C3CC(CN3C1=O)OC(=O)N4CC5=C(C4)C(=CC=C5)F)C(=O)NS(=O)(=O)C6CC6 IUPAC Name [(1S,4R,6S,7Z,14S,18R)-4-(cyclopropylsulfonylcarbamoyl)-14-[(2-methylpropan-2-yl)oxycarbonylamino]-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-en-18-yl] 4-fluoro-1,3-dihydroisoindole-2-carboxylate InChIKey ZVTDLPBHTSMEJZ-JSZLBQEHSA-N INCHI 1S/C35H46FN5O9S/c1-34(2,3)50-32(45)37-27-13-8-6-4-5-7-11-22-17-35(22,31(44)39-51(47,48)24-14-15-24)38-29(42)28-16-23(19-41(28)30(27)43)49-33(46)40-18-21-10-9-12-26(36)25(21)20-40/h7,9-12,22-24,27-28H,4-6,8,13-20H2,1-3H3,(H,37,45)(H,38,42)(H,39,44)/b11-7-/t22-,23-,27+,28+,35-/m1/s1 Isomeric SMILES CC(C)(C)OC(=O)N[C@H]1CCCCC/C=C\[C@@H]2C[C@]2(NC(=O)[C@@H]3C[C@H](CN3C1=O)OC(=O)N4CC5=C(C4)C(=CC=C5)F)C(=O)NS(=O)(=O)C6CC6 Molecular Weight 731.85 Reaxy-Rn 31131204 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=31131204&ln=
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organic acids and derivatives Class Carboxylic acids and derivatives Subclass Amino acids, peptides, and analogues Intermediate Tree Nodes Peptides Direct Parent Cyclic peptides Alternative Parents Macrolactams Alpha amino acid amides Isoindoles Isoindolines Aryl fluorides Benzenoids Cyclopropanecarboxylic acids and derivatives Tertiary carboxylic acid amides Pyrrolidines Organosulfonic acids and derivatives Aminosulfonyl compounds Carbamate esters Secondary carboxylic acid amides Organic carbonic acids and derivatives Lactams Azacyclic compounds Carbonyl compounds Organic oxides Organofluorides Organopnictogen compounds Hydrocarbon derivatives Organonitrogen compounds Molecular Framework Aromatic heteropolycyclic compounds Substituents Cyclic alpha peptide - Macrolactam - Alpha-amino acid amide - Alpha-amino acid or derivatives - Isoindoline - Isoindole - Isoindole or derivatives - Aryl fluoride - Aryl halide - Cyclopropanecarboxylic acid or derivatives - Benzenoid - Aminosulfonyl compound - Carbamic acid ester - Tertiary carboxylic acid amide - Pyrrolidine - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Sulfonyl - Carboxamide group - Secondary carboxylic acid amide - Carbonic acid derivative - Lactam - Azacycle - Organoheterocyclic compound - Organonitrogen compound - Organic oxygen compound - Organic nitrogen compound - Organohalogen compound - Hydrocarbon derivative - Organooxygen compound - Organosulfur compound - Organopnictogen compound - Organofluoride - Organic oxide - Carbonyl group - Aromatic heteropolycyclic compound Description This compound belongs to the class of organic compounds known as cyclic peptides. These are compounds containing a cyclic moiety bearing a peptide backbone. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solubility DMSO 144 mg/mL Water <1 mg/mL Ethanol 144 mg/mL Molecular Weight 731.800 g/mol XLogP3 3.300 Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 10 Rotatable Bond Count 8 Exact Mass 731.3 Da Monoisotopic Mass 731.3 Da Topological Polar Surface Area 189.000 Ų Heavy Atom Count 51 Formal Charge 0 Complexity 1530.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 5 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 1 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 1 Covalently-Bonded Unit Count 1
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