DDO-2093 dihydrochloride - ≥98% , CAS No.D658611

CAS: D658611 Cat. No.: D658611 Molecular Weight: 687.04

GRADE & PURITY ≥98%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Overview

DDO-2093 dihydrochloride is a potent MLL1-WDR5 protein-protein interaction inhibitor ( IC 50 =8.6 nM; K d =11.6 nM) with antitumor activity. DDO-2093 dihydrochloride selectively inhibits the catalytic activity of MLL complex.

Appearance:Solid

In Vitro:DDO-2093 (5 μM; pretreated 7 days) dihydrochloride inhibits MLL-fusion protein dependent genes expression ( HOXA9 and Meis1 ). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisC

In Vivo:DDO-2093 (20-80mg/kg; i.p.; every other day for 21 days) dihydrochloride significantly suppresses the tumor size and weight in a dose-dependent manner. MCE has not independently confirmed the accuracy of these methods. They are for reference only. A

Biological Activity:DDO-2093 dihydrochloride is a potent MLL1-WDR5 protein-protein interaction inhibitor ( IC 50 =8.6 nM; K d =11.6 nM) with antitumor activity. DDO-2093 dihydrochloride selectively inhibits the catalytic activity of MLL complex.

Specifications

Specifications & Purity

≥98%

Storage

Store at 2-8°C, Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥98%

Names and Identifiers

• Molecular Weight: 687.04