10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 2 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Dibenzazepine (YO-01027, DBZ) is a dipeptidicγ-secretaseinhibitor withIC50of 2.6 nM and 2.9 nM in cell-free assays forAPPLandNotchcleavage, respectively.
In vitro
YO-01027 interacts directly with theγ-secretase complex and targets the N-terminal Presenilin fragment. Increasing concentrations of YO-01027 administered to APPL- or Notch-expressing cells leads to the progressive accumulation of APPL CTF fragments and a decrease in NICD production in a strictly dose-dependent manner. 10 μM of YO-01027 reduces breast cancer stem cells (BCSC) number and activity. A recent research indicates YO-01027 impairs mucin protein MUC16 biosynthesis in a concentration-dependent manner in undifferentiated cells at both preconfluent and confluent stages through Notch inhibition, but not in postmitotic stratified cells.
In vivo
YO-01027, which is delivered 1 mg/mL by i.p. injection on the day of cell injection and every subsequent 3 days, YO-01027 significantly, decreases MCF7 but not MDA-MB-231 tumors and increases latency compared with control mice (18-28 days). YO-01027-treated MCF7 tumors that did form had significantly reduced tumor volumes. Treatment of YO-01027 into C57BL/6 mice inhibits epithelial cell proliferation and induces goblet cell differentiation in intestinal adenomas in a dose-dependent manner.
Cell Data
cell lines：
Concentrations：10 μM
Incubation Time：3 days
Powder Purity:≥97%
| Isomeric SMILES | C[C@@H](C(=O)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)CC4=CC(=CC(=C4)F)F |
|---|---|
| WGK Germany | 3 |
| PubChem CID | 11454028 |
| Molecular Weight | 463.48 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Solubility | Solubility (25°C) In vitro Water: 27 mg/mL (199.73 mM); DMSO: Insoluble; Ethanol: Insoluble; |
|---|
| 1. Fei Wang, Fan Yang, Jiawei Liu, Quan Bai. (2023) Studies on the retention mechanism of solutes in hydrophilic interaction chromatography using stoichiometric displacement theory II. HILIC/RPLC dual-retention mechanism of solutes in hydrophilic interaction chromatography over the entire range of water concentration in mobile phase. TALANTA, [PMID:37385194] [10.1016/j.talanta.2023.124858] |
| 2. Zuoxin Hu, Yu Qiu, Jicheng Zhou, Qing Li. (2024) Smart Flexible Porous Bilayer for All-Day Dynamic Passive Cooling. Small Science, 4 (3): (2300237). [PMID:] [10.1002/smsc.202300237] |
