Dibutyryl-Cyclic GMP (sodium salt) - ≥98% , CAS No.51116-00-8

CAS: 51116-00-8 Cat. No.: D276144 Molecular Weight: 507.37 PubChem CID: 136069596

GRADE & PURITY ≥98%

Synonyms

EINECS 256-992-2 | Dibutyryl-Cyclic GMP (sodium salt) | Guanosine, N-(1-oxobutyl)-, cyclic 3',5'-(hydrogen phosphate) 2'-butanoate, monosodium salt | n2,2'-O-Dibutyrylguanosine 3':5'-cyclic monophosphate sodium salt | Dibutyryl-cgmp sodium salt | sodium;[

Storage

Store at -20°C,Argon charged,Desiccated

Shipped In

Ice chest + Ice pads

Overview

Dibutyryl-cyclic GMP (dibutyryl-cGMP) is a cell-permeable, cGMP analog that activates cGMP-dependent protein kinase. It has been used in a wide variety of research applications to mimic cGMP interactions and effects on different biological molecules.

Specifications

Synonyms

EINECS 256-992-2 | Dibutyryl-Cyclic GMP (sodium salt) | Guanosine, N-(1-oxobutyl)-, cyclic 3', 5'-(hydrogen phosphate) 2'-butanoate, monosodium salt | n2, 2'-O-Dibutyrylguanosine 3':5'-cyclic monophosphate sodium salt | Dibutyryl-cgmp sodium salt | sodium;[

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Cell-permeable cGMP analog. Activates Protein Kinase G (PKG). Raises intracellular Ca 2+ concentrations similar to 8-Br-cGMP . Shows antinociceptive effects in vivo.

Storage

Store at -20°C, Argon charged, Desiccated

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

ACTIVATOR

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 504773459
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504773459
• Canonical Smiles: CCCC(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C4C(O3)COP(=O)(O4)[O-])OC(=O)CCC.[Na+]
• IUPAC Name: sodium;[(4aR,6R,7R,7aR)-6-[2-(butanoylamino)-6-oxo-1H-purin-9-yl]-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-yl] butanoate
• InChIKey: MGBPJXVWDGGLKI-GBIKJYCISA-M
• INCHI: 1S/C18H24N5O9P.Na/c1-3-5-10(24)20-18-21-15-12(16(26)22-18)19-8-23(15)17-14(31-11(25)6-4-2)13-9(30-17)7-29-33(27,28)32-13;/h8-9,13-14,17H,3-7H2,1-2H3,(H,27,28)(H2,20,21,22,24,26);/q;+1/p-1/t9-,13-,14-,17-;/m1./s1
• Isomeric SMILES: CCCC(=O)NC1=NC2=C(C(=O)N1)N=CN2[C@H]3[C@@H]([C@H]4[C@H](O3)COP(=O)(O4)[O-])OC(=O)CCC.[Na+]
• PubChem CID: 136069596
• Molecular Weight: 507.37

Chemical and Physical Properties

• Solubility: Soluble in water to 100 mM and in ethanol
• Sensitivity: Moisture sensitive