Divalproex Sodium - ≥99% , Succinate semialdehyde dehydrogenase inhibitor, CAS No.76584-70-8, Succinate semialdehyde dehydrogenase inhibitor

CAS: 76584-70-8 Cat. No.: D412711 Molecular Weight: 311.42 EC Number: 630-325-9

GRADE & PURITY ≥99%

Synonyms

Depakote | DTXSID70227388 | Natrium hydrogen bis(2-propylvalerat) | Valparin | Valproate semisodique [French] | C76453 | Valproic acid semisodium salt (2:1) | CHEBI:4667 | Depakote (TN) | Valproate semisodium [INN] | Epilex | Valproatum seminatricum (Lati

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Information

Divalproex Sodium Divalproex Sodium, consisting of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form, is a HDAC inhibitor, used in the treatment for epilepsy.

Targets

HDAC

In vitro

Divalproex sodium enhances IM-induced cell growth inhibition, apoptosis and cell cycle arrest in K562-S and K562-G cells. Divalproex sodium enhances the inhibitory effects of IM on SIRT1 expression in K562-S and K562-G cells. Divalproex sodium enhances the effect of IM on apoptosis in K562-G cells partly through SIRT1. Divalproex (500 mg/kg) significantly increases dopamine (DA) and acetylcholine (ACh) efflux in the rat hippocampus, and DA, but not ACh, efflux in the rat medial prefrontal cortex (mPFC), whereas a lower dose of Divalproex, 50 mg/kg, has no effect on DA or ACh in either region. Divalproex (50 mg/kg) combined with the atypical APDs Olanzapine (1.0 mg/kg) or Aripiprazole (0.3 mg/kg) significantly potentiates the effect of both antipsychotic drugs (APDs) on DA, but not ACh efflux in the HIP and mPFC.

Specifications

Synonyms

Depakote | DTXSID70227388 | Natrium hydrogen bis(2-propylvalerat) | Valparin | Valproate semisodique [French] | C76453 | Valproic acid semisodium salt (2:1) | CHEBI:4667 | Depakote (TN) | Valproate semisodium [INN] | Epilex | Valproatum seminatricum (Lati

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

Divalproex Sodium, consisting of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form, is a HDAC inhibitor, used in the treatment for epilepsy.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Mechanism of action

Succinate semialdehyde dehydrogenase inhibitor

Purity

≥99%

Names and Identifiers

• Pubchem Sid: 488200394
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488200394
• Canonical Smiles: CCCC(CCC)C(=O)O.CCCC(CCC)C(=O)[O-].[Na+]
• IUPAC Name: sodium;2-propylpentanoate;2-propylpentanoic acid
• InChIKey: MSRILKIQRXUYCT-UHFFFAOYSA-M
• INCHI: 1S/2C8H16O2.Na/c2*1-3-5-7(6-4-2)8(9)10;/h2*7H,3-6H2,1-2H3,(H,9,10);/q;;+1/p-1
• Isomeric SMILES: CCCC(CCC)C(=O)O.CCCC(CCC)C(=O)[O-].[Na+]
• Molecular Weight: 311.42
• Reaxy-Rn: 8462424
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8462424&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Lipids and lipid-like molecules
    • Class Fatty Acyls
      • Subclass Fatty acids and conjugates

• Kingdom: Organic compounds
• Superclass: Lipids and lipid-like molecules
• Class: Fatty Acyls
• Subclass: Fatty acids and conjugates
• Intermediate Tree Nodes: Not available
• Direct Parent: Fatty acids and conjugates
• Alternative Parents: Organic alkali metal salts Monocarboxylic acids and derivatives Carboxylic acids Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Not available
• Substituents: Fatty acid - Organic alkali metal salt - Monocarboxylic acid or derivatives - Carboxylic acid - Carboxylic acid derivative - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organic salt - Organooxygen compound - Carbonyl group - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as fatty acids and conjugates. These are aliphatic monocarboxylic acids with a saturated or unsaturated aliphatic tail (with at least 4 Carbon atoms).
• External Descriptors: organic sodium salt

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

Homo sapiens (32628 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 62 mg/mL (199.73 mM); Water: 62 mg/mL (199.73 mM); Ethanol: 62 mg/mL (199.73 mM)
• Molecular Weight: 310.400 g/mol
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 10
• Exact Mass: 310.212 Da
• Monoisotopic Mass: 310.212 Da
• Topological Polar Surface Area: 77.400 Ų
• Heavy Atom Count: 21
• Formal Charge: 0
• Complexity: 192.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 3

XLogP3