DYRK1-IN-1 - ≥99% , CAS No.D659448

CAS: D659448 Cat. No.: D659448 Molecular Weight: 240.26

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

DYRK1-IN-1 is a highly selective and ligand-efficient DYRK1A inhibitor. DYRK1-IN-1 inhibits DYRK1A phosphorylation activity with an IC 50 value of 220 nM. DYRK1-IN-1 can be used for the research of central nervous system penetrant DYRK1A chemical probe.

Appearance:Solid

IC50& Target:DYRK1A 220 nM (IC 50 ) DYRK1A 3 nM (Kd) DYRK1B 56 nM (Kd)

In Vitro:DYRK1-IN-1 inhibits DYRK1A phosphorylation activity with an IC 50 value of 220 nM. DYRK1-IN-1 inhibits tau phosphorylation with an IC 50 value of 0.59 μM. DYRK1-IN-1 exhibits good permeability and cellular activity without P-glycoprotein liability. DYRK1-

In Vivo:DYRK1-IN-1 (1mg/kg; i.v.) shows high clearance. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Sprague−Dawley ratsDosage: 1mg/kg (Pharmacokinetic Analysis) Administration: I.v. Res

Biological Activity:DYRK1-IN-1 is a highly selective and ligand-efficient DYRK1A inhibitor. DYRK1-IN-1 inhibits DYRK1A phosphorylation activity with an IC 50 value of 220 nM. DYRK1-IN-1 can be used for the research of central nervous system penetrant DYRK1A chemical probe.

Specifications

Specifications & Purity

≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥99%

Names and Identifiers

• Molecular Weight: 240.26

Chemical and Physical Properties

• Solubility: DMSO : 25 mg/mL (104.05 mM; ultrasonic and warming and heat to 60°C)