Famotidine - Moligand™, 10mM in DMSO , Histamine H2 receptor antagonist, CAS No.76824-35-6, Histamine H2 receptor antagonist

CAS: 76824-35-6 Cat. No.: F408164 Molecular Weight: 337.45 EC Number: 616-396-9

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

MK208 | 3-​[[[2-​[(aminoiminomethyl)​amino]​-​4-​thiazolyl]​methyl]​thio]​-​N-​(aminosulfonyl)​-propanimidamide

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Famotidine (MK208) is a histamine H2–receptor antagonist with IC50 of 0.6 mM, commonly used to treat heartburn, GERD, ulcers, and other digestive conditions.
In vitro

In vivo

Cell Data

cell lines：HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji and PC-3 cells, etc.

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

MK208 | 3-​[[[2-​[(aminoiminomethyl)​amino]​-​4-​thiazolyl]​methyl]​thio]​-​N-​(aminosulfonyl)​-propanimidamide

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Famotidine (MK208) is a histamine H2–receptor antagonist with IC50 of 0.6 mM, commonly used to treat heartburn, GERD, ulcers, and other digestive conditions.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

AGONIST, ANTAGONIST

Mechanism of action

Histamine H2 receptor antagonist

Product Properties

• ALogP: -0.6

Names and Identifiers

• Isomeric SMILES: C1=C(N=C(S1)N=C(N)N)CSCC/C(=N/S(=O)(=O)N)/N
• WGK Germany: 2
• RTECS: UA2300000
• Molecular Weight: 337.45
• Reaxy-Rn: 5767271
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5767271&ln=

Associated Targets(Human)

HRH2 Tclin Histamine H2 receptor (0 Activities)

Discover Target: HRH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TAS2R31 Tchem Taste receptor type 2 member 31 (0 Activities)

Discover Target: TAS2R31

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro DMSO: 55 mg/mL (198.35 mM); Water: Insoluble; Ethanol: Insoluble
• Melt Point(°C): 166-168°C

References

1. Guodong Shan, Xiuqin Fan, Qingcheng Wang, Li Zhang, Lijun Ge, Weibo Lu, Jing Xue, Kang Chen, Zejun Wang, Qing Shen.  (2025)  Development of a Captiva EMR-lipid clean-up and LC-MS/MS methodology for detecting H2 receptor antagonists in functional foods and food-medicine homology materials.  Applied Food Research,      [PMID:] [10.1016/j.afres.2025.100772]