What are the key criteria for selecting stable isotope-labeled standards for clinical measurements?
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What are the key criteria for selecting stable isotope-labeled standards for clinical measurements?
·Reviewed·Published ·Updated ·8 min read
What are the key criteria for selecting stable isotope-labeled standards for clinical measurements?
These exogenous compounds must be structurally unique (within a given sample type) and similar (to the native target, from a physicochemical standpoint) as well as resolvable by MS (≥3 Da generally preferred), free from H/D exchange (if D standards are employed), and ideally co-elute (with their native target).
Da — when not otherwise indicated, molecular weight units are daltons. Mw — weight-average molecular weight. Mn — number-average molecular weight.
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Aladdin Scientific. "What are the key criteria for selecting stable isotope-labeled standards for clinical measurements?" Aladdin Knowledge Base, updated Oct 9, 2023. https://www.aladdinsci.com/us_en/faqs/What-are-the-key-criteria-for-selecting-stable-isotope-labeled-standards-for-clinical-measurements-en.html
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