What is the relationship between the specific activity expressed as an ED50 and as units/mg?
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What is the relationship between the specific activity expressed as an ED50 and as units/mg?
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What is the relationship between the specific activity expressed as an ED50 and as units/mg?
While ED50 is defined as the cytokine concentration at which activity is 50% of the maximum response, specific activity is defined as a measurement of reaction rate (i.e. activity) in relation to the amount or mass of a substance. Specific Activity Units should only be used as a method of expressing potency and should only be calculated for sigmoidal dose-dependent curves. The formula for converting activity expressed as an ED50 in ng/ml to specific activity in units/mg is:
Da — when not otherwise indicated, molecular weight units are daltons. Mw — weight-average molecular weight. Mn — number-average molecular weight.
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Aladdin Scientific. "What is the relationship between the specific activity expressed as an ED50 and as units/mg?" Aladdin Knowledge Base, updated Oct 9, 2023. https://www.aladdinsci.com/us_en/faqs/what-is-the-relationship-between-the-specific-activity-expressed-as-an-ed50-and-as-units-mg-en.html
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