≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
FEN1 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a, both frequently mutated in colorectal cancers. FEN1 has also emerged as a potential chemosensitizing target due to its role in LP-BER since it is critical for repair of Methyl methanesulfonate-induced alkylation damage, and its knockdown or inhibition increases sensitivity to Temozolomide in glioblastoma and colorectal cancer cell lines.
| Pubchem Sid | 504772919 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504772919 |
| Canonical Smiles | C1CC1CN2C3=CC=CC=C3C(=O)N(C2=O)O |
| IUPAC Name | 1-(cyclopropylmethyl)-3-hydroxyquinazoline-2,4-dione |
| InChIKey | JAFLWTUYSKADJS-UHFFFAOYSA-N |
| INCHI | 1S/C12H12N2O3/c15-11-9-3-1-2-4-10(9)13(7-8-5-6-8)12(16)14(11)17/h1-4,8,17H,5-7H2 |
| Molecular Weight | 232.24 |
| Reaxy-Rn | 32412266 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=32412266&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 I2201462 | Certificate of Analysis | Jun 10, 2025 | F412918 |
| I2201465 | Certificate of Analysis | Jun 10, 2025 | F412918 |
| I2201466 | Certificate of Analysis | Jun 10, 2025 | F412918 |
| H2513136 | Certificate of Analysis | Sep 25, 2024 | F412918 |
| J2410545 | Certificate of Analysis | Sep 25, 2024 | F412918 |
| J2410548 | Certificate of Analysis | Sep 25, 2024 | F412918 |
| J2410549 | Certificate of Analysis | Sep 25, 2024 | F412918 |
| J2410551 | Certificate of Analysis | Sep 25, 2024 | F412918 |
| J2410554 | Certificate of Analysis | Sep 25, 2024 | F412918 |
| J2410555 | Certificate of Analysis | Sep 25, 2024 | F412918 |
| J2410556 | Certificate of Analysis | Sep 25, 2024 | F412918 |
| B2429023 | Certificate of Analysis | Jun 27, 2022 | F412918 |
| I2201463 | Certificate of Analysis | Jun 27, 2022 | F412918 |
| I2201464 | Certificate of Analysis | Jun 27, 2022 | F412918 |
| Solubility | Solubility (25°C) In vitro DMSO: 46 mg/mL (198.07 mM); Ethanol: 46 mg/mL (198.07 mM); Water: Insoluble; |
|---|---|
| Molecular Weight | 232.230 g/mol |
| XLogP3 | 1.100 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 2 |
| Exact Mass | 232.085 Da |
| Monoisotopic Mass | 232.085 Da |
| Topological Polar Surface Area | 60.900 Ų |
| Heavy Atom Count | 17 |
| Formal Charge | 0 |
| Complexity | 354.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
