FH535 - ≥98% , CAS No.108409-83-2

CAS: 108409-83-2 Cat. No.: F127654 Molecular Weight: 361.2 EC Number: 664-041-1

COA

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FH535 - ≥98% CAS No(108409-83-2) by Aladdin Scientific

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AVAILABLE TO ORDER

GRADE & PURITY ≥98%

Synonyms

FH535 | FH-535 | HB0288 | HMS3653N07 | BDBM50509999 | FH535, >=98% (HPLC) | SB19433 | HY-15721 | J-002138 | C13H10Cl2N2O4S | EX-A388 | SMSF0005619 | N-(2-Methyl-4-nitrophenyl)-2,5-dichlorobenzenesulfonamide | beta-Catenin/Tcf Inhibitor, FH535 | beta -Cate

Storage

Store at 2-8°C

Shipped In

Wet ice

Overview Specifications Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solution Calculators Reviews

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Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

FH535 is a Wnt/β-catenin signaling inhibitor and also a dual PPARγ and PPARδ antagonist.
A cell-permeable compound that inhibits Wnt/β-catenin and PPAR

Specifications

Synonyms

FH535 | FH-535 | HB0288 | HMS3653N07 | BDBM50509999 | FH535, >=98% (HPLC) | SB19433 | HY-15721 | J-002138 | C13H10Cl2N2O4S | EX-A388 | SMSF0005619 | N-(2-Methyl-4-nitrophenyl)-2, 5-dichlorobenzenesulfonamide | beta-Catenin/Tcf Inhibitor, FH535 | beta -Cate

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

Description:IC50 Value: 1.1uM (Cytotoxicity in the CCLP-1 cell line) [1] FH535 is a compound that suppresses both Wnt/beta-catenin and peroxisome proliferator-activated receptor (PPAR) signaling. FH535antagonizes both PPAR gamma and PPAR delta ligand

Storage

Store at 2-8°C

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥98%

Names and Identifiers

Canonical Smiles	CC1=C(C=CC(=C1)[N+](=O)[O-])NS(=O)(=O)C2=C(C=CC(=C2)Cl)Cl
IUPAC Name	2,5-dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide
InChIKey	AXNUEXXEQGQWPA-UHFFFAOYSA-N
INCHI	1S/C13H10Cl2N2O4S/c1-8-6-10(17(18)19)3-5-12(8)16-22(20,21)13-7-9(14)2-4-11(13)15/h2-7,16H,1H3
Isomeric SMILES	CC1=C(C=CC(=C1)[N+](=O)[O-])NS(=O)(=O)C2=C(C=CC(=C2)Cl)Cl
Molecular Weight	361.2
Reaxy-Rn	28463026
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=28463026&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Benzenoids
  - Class Benzene and substituted derivatives
    - Subclass Sulfanilides

Kingdom	Organic compounds
Superclass	Benzenoids
Class	Benzene and substituted derivatives
Subclass	Sulfanilides
Intermediate Tree Nodes	Not available
Direct Parent	Sulfanilides
Alternative Parents	Benzenesulfonamides Benzenesulfonyl compounds Nitrobenzenes Nitrotoluenes Dichlorobenzenes Nitroaromatic compounds Aryl chlorides Organosulfonamides Aminosulfonyl compounds Propargyl-type 1,3-dipolar organic compounds Organic oxoazanium compounds Organic oxides Organonitrogen compounds Organopnictogen compounds Hydrocarbon derivatives Organochlorides
Molecular Framework	Aromatic homomonocyclic compounds
Substituents	Benzenesulfonamide - Sulfanilide - Nitrobenzene - Nitrotoluene - Benzenesulfonyl group - 1,4-dichlorobenzene - Nitroaromatic compound - Chlorobenzene - Halobenzene - Toluene - Aryl halide - Aryl chloride - Organosulfonic acid amide - Organic sulfonic acid or derivatives - Aminosulfonyl compound - Sulfonyl - Organosulfonic acid or derivatives - Organic nitro compound - C-nitro compound - Organic oxoazanium - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Allyl-type 1,3-dipolar organic compound - Organosulfur compound - Organonitrogen compound - Organochloride - Organohalogen compound - Organopnictogen compound - Organic oxygen compound - Hydrocarbon derivative - Organic nitrogen compound - Organic oxide - Aromatic homomonocyclic compound
Description	This compound belongs to the class of organic compounds known as sulfanilides. These are organic aromatic compounds containing a sulfanilide moiety, with the general structure RS(=O)(=O)NC1=CC=CC=C1.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(Human)

5637 (630 Activities)

Lot Number	Certificate Type	Date	Item
F2418004	Certificate of Analysis	Apr 02, 2026	F127654
H1813151	Certificate of Analysis	Nov 06, 2025	F127654
H1813150	Certificate of Analysis	Nov 06, 2025	F127654
H1602011	Certificate of Analysis	Sep 16, 2025	F127654

Solubility	25°C: DMSO
Refractive Index	1.65
Boil Point(°C)	~526.3° C at 760 mmHg
Melt Point(°C)	202.89°C
Molecular Weight	361.200 g/mol
XLogP3	3.900
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	3
Exact Mass	359.974 Da
Monoisotopic Mass	359.974 Da
Topological Polar Surface Area	100.000 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	505.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1