≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
GCN2iB GCN2iB is an ATP-competitive serine/threonine-protein kinase general control nonderepressible 2 (GCN2) inhibitor with IC50 of 2.4 nM.
Targets
GCN2 (Cell-free assay) 2.4 nM
Cell Research(from reference)
Cell lines：Pancreatic cancer cells, CCRF-CEM cells, MEF cells (GCN2-WT or -KO), CCRF-CEM, MV-4-11, SU.86.86 cells
Concentrations：37 nM, 110 nM, 330 nM, 1.0 μM
Incubation Time：4 h, 72 h
Product Application：
GCN2iB is an intermediate used in the preparation of heterocyclic compounds as GCN2 inhibitors.
| Pubchem Sid | 488202809 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488202809 |
| Canonical Smiles | COC1=C(C=C(C=N1)Cl)S(=O)(=O)NC2=C(C(=C(C=C2)F)C#CC3=CN=C(N=C3)N)F |
| IUPAC Name | N-[3-[2-(2-aminopyrimidin-5-yl)ethynyl]-2,4-difluorophenyl]-5-chloro-2-methoxypyridine-3-sulfonamide |
| InChIKey | JGHVXJKGYJYWOP-UHFFFAOYSA-N |
| INCHI | 1S/C18H12ClF2N5O3S/c1-29-17-15(6-11(19)9-23-17)30(27,28)26-14-5-4-13(20)12(16(14)21)3-2-10-7-24-18(22)25-8-10/h4-9,26H,1H3,(H2,22,24,25) |
| Molecular Weight | 451.83 |
| Reaxy-Rn | 34297301 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=34297301&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Class | Pyridines and derivatives |
| Subclass | Pyridinesulfonamides |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Pyridinesulfonamides |
| Alternative Parents | Sulfanilides Fluorobenzenes Aminopyrimidines and derivatives Alkyl aryl ethers Organosulfonamides Aryl fluorides Aryl chlorides Heteroaromatic compounds Aminosulfonyl compounds Azacyclic compounds Primary amines Organopnictogen compounds Organofluorides Organochlorides Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteromonocyclic compounds |
| Substituents | Sulfanilide - Pyridine-3-sulfonamide - Halobenzene - Fluorobenzene - Aminopyrimidine - Alkyl aryl ether - Benzenoid - Organosulfonic acid amide - Pyrimidine - Monocyclic benzene moiety - Aryl halide - Aryl fluoride - Aryl chloride - Heteroaromatic compound - Aminosulfonyl compound - Sulfonyl - Organosulfonic acid or derivatives - Organic sulfonic acid or derivatives - Azacycle - Ether - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Primary amine - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Organofluoride - Organochloride - Organohalogen compound - Amine - Aromatic heteromonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as pyridinesulfonamides. These are heterocyclic compounds containing a pyridine ring substituted by one or more sulfonamide groups. |
| External Descriptors | Not available |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 D2301378 | Certificate of Analysis | Jan 21, 2026 | G414275 |
| D2301379 | Certificate of Analysis | Jan 21, 2026 | G414275 |
| D2301380 | Certificate of Analysis | Jan 21, 2026 | G414275 |
| D2301384 | Certificate of Analysis | Jan 21, 2026 | G414275 |
| D2301385 | Certificate of Analysis | Jan 21, 2026 | G414275 |
| D2301389 | Certificate of Analysis | Jan 21, 2026 | G414275 |
| D2301390 | Certificate of Analysis | Jan 21, 2026 | G414275 |
| D2301391 | Certificate of Analysis | Jan 21, 2026 | G414275 |
| Solubility | Solubility (25°C) In vitro DMSO: 15 mg/mL (33.19 mM); Water: Insoluble; Ethanol: Insoluble; |
|---|---|
| Molecular Weight | 451.800 g/mol |
| XLogP3 | 2.500 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 10 |
| Rotatable Bond Count | 6 |
| Exact Mass | 451.032 Da |
| Monoisotopic Mass | 451.032 Da |
| Topological Polar Surface Area | 128.000 Ų |
| Heavy Atom Count | 30 |
| Formal Charge | 0 |
| Complexity | 750.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
